2z35

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[[Image:2z35.gif|left|200px]]
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{{Seed}}
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[[Image:2z35.png|left|200px]]
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{{STRUCTURE_2z35| PDB=2z35 | SCENE= }}
{{STRUCTURE_2z35| PDB=2z35 | SCENE= }}
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'''Crystal structure of immune receptor'''
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===Crystal structure of immune receptor===
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==Overview==
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All complexes of T cell receptors (TCRs) bound to peptide-major histocompatibility complex (pMHC) molecules assume a stereotyped binding 'polarity', despite wide variations in TCR-pMHC docking angles. However, existing TCR-pMHC crystal structures have failed to show broadly conserved pairwise interaction motifs. Here we determined the crystal structures of two TCRs encoded by the variable beta-chain 8.2 (V(beta)8.2), each bound to the MHC class II molecule I-A(u), and did energetic mapping of V(alpha) and V(beta) contacts with I-A(u). Together with two previously solved structures of V(beta)8.2-containing TCR-MHC complexes, we found four TCR-I-A complexes with structurally superimposable interactions between the V(beta) loops and the I-A alpha-helix. This examination of a narrow 'slice' of the TCR-MHC repertoire demonstrates what is probably one of many germline-derived TCR-MHC interaction 'codons'.
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The line below this paragraph, {{ABSTRACT_PUBMED_17694060}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17694060 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17694060}}
==About this Structure==
==About this Structure==
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[[Category: Immune receptor]]
[[Category: Immune receptor]]
[[Category: Immune system]]
[[Category: Immune system]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 19:53:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:28:52 2008''

Revision as of 12:28, 27 July 2008

Image:2z35.png

Template:STRUCTURE 2z35

Crystal structure of immune receptor

Template:ABSTRACT PUBMED 17694060

About this Structure

Full crystallographic information is available from OCA.

Reference

Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'., Feng D, Bond CJ, Ely LK, Maynard J, Garcia KC, Nat Immunol. 2007 Sep;8(9):975-83. Epub 2007 Aug 12. PMID:17694060

Page seeded by OCA on Sun Jul 27 15:28:52 2008

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