1ont

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[[Image:1ont.gif|left|200px]]
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{{STRUCTURE_1ont| PDB=1ont | SCENE= }}
{{STRUCTURE_1ont| PDB=1ont | SCENE= }}
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'''NMDA RECEPTOR ANTAGONIST, CONANTOKIN-T, NMR, 17 STRUCTURES'''
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===NMDA RECEPTOR ANTAGONIST, CONANTOKIN-T, NMR, 17 STRUCTURES===
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==Overview==
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Conantokin-G and conantokin-T are two paralytic polypeptide toxins originally isolated from the venom of the fish-hunting cone snails of the genus Conus. Conantokin-G and conantokin-T are the only naturally occurring peptidic compounds which possess N-methyl-D-aspartate receptor antagonist activity, produced by a selective non-competitive antagonism of polyamine responses. They are also structurally unusual in that they contain a disproportionately large number of acid labile post-translational gamma-carboxyglutamic acid (Gla) residues. Although no precise structural information has previously been published for these peptides, early spectroscopic measurements have indicated that both conantokin-G and conantokin-T form alpha-helical structures, although there is some debate whether the presence of calcium ions is required for these peptides to adopt this fold. We now report a detailed structural study of synthetic conantokin-G and conantokin-T in a range of solution conditions using CD and 1H NMR spectroscopy. The three-dimensional structures of conantokin-T and conantokin-G were calculated from 1H NMR-derived distance and dihedral restraints. Both conantokins were found to contain a mixture of alpha- and 310 helix, that give rise to curved and straight helical conformers. Conantokin-G requires the presence of divalent cations (Zn2+, Ca2+, Cu2+, or Mg2+) to form a stable alpha-helix, while conantokin-T adopts a stable alpha-helical structure in aqueous conditions, in the presence or absence of divalent cations (Zn2+, Ca2+, Cu2+, or Mg2+).
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{{ABSTRACT_PUBMED_8999936}}
==About this Structure==
==About this Structure==
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1ONT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_tulipa Conus tulipa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ONT OCA].
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1ONT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_tulipa Conus tulipa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ONT OCA].
==Reference==
==Reference==
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[[Category: Conantokin-t]]
[[Category: Conantokin-t]]
[[Category: Nmda receptor]]
[[Category: Nmda receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:30:12 2008''

Revision as of 12:30, 27 July 2008

Image:1ont.png

Template:STRUCTURE 1ont

NMDA RECEPTOR ANTAGONIST, CONANTOKIN-T, NMR, 17 STRUCTURES

Template:ABSTRACT PUBMED 8999936

About this Structure

1ONT is a Single protein structure of sequence from Conus tulipa. Full experimental information is available from OCA.

Reference

Determination of the solution structures of conantokin-G and conantokin-T by CD and NMR spectroscopy., Skjaerbaek N, Nielsen KJ, Lewis RJ, Alewood P, Craik DJ, J Biol Chem. 1997 Jan 24;272(4):2291-9. PMID:8999936

Page seeded by OCA on Sun Jul 27 15:30:12 2008

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