2fuf

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[[Image:2fuf.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2fuf| PDB=2fuf | SCENE= }}
{{STRUCTURE_2fuf| PDB=2fuf | SCENE= }}
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'''Crystal structure of the SV40 large T antigen origin-binding domain'''
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===Crystal structure of the SV40 large T antigen origin-binding domain===
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==Overview==
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The origins of replication of DNA tumor viruses have a highly conserved feature, namely, multiple binding sites for their respective initiator proteins arranged as inverted repeats. In the 1.45-angstroms crystal structure of the simian virus 40 large T-antigen (T-ag) origin-binding domain (obd) reported herein, T-ag obd monomers form a left-handed spiral with an inner channel of 30 angstroms having six monomers per turn. The inner surface of the spiral is positively charged and includes residues known to bind DNA. Residues implicated in hexamerization of full-length T-ag are located at the interface between adjacent T-ag obd monomers. These data provide a high-resolution model of the hexamer of origin-binding domains observed in electron microscopy studies and allow the obd's to be oriented relative to the hexamer of T-ag helicase domains to which they are connected.
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The line below this paragraph, {{ABSTRACT_PUBMED_16611889}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16611889 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16611889}}
==About this Structure==
==About this Structure==
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[[Category: Dna replication]]
[[Category: Dna replication]]
[[Category: Replication origin binding domain]]
[[Category: Replication origin binding domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:19:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:32:23 2008''

Revision as of 12:32, 27 July 2008

Image:2fuf.png

Template:STRUCTURE 2fuf

Crystal structure of the SV40 large T antigen origin-binding domain

Template:ABSTRACT PUBMED 16611889

About this Structure

2FUF is a Single protein structure of sequence from Simian virus 40. Full crystallographic information is available from OCA.

Reference

Crystal structure of the simian virus 40 large T-antigen origin-binding domain., Meinke G, Bullock PA, Bohm A, J Virol. 2006 May;80(9):4304-12. PMID:16611889

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