2h2k

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{{STRUCTURE_2h2k| PDB=2h2k | SCENE= }}
{{STRUCTURE_2h2k| PDB=2h2k | SCENE= }}
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'''Crystal Structure Analysis of Human S100A13'''
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===Crystal Structure Analysis of Human S100A13===
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==Overview==
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The S100 protein family is the largest group of calcium-binding protein families, which consists of at least 25 members. S100A13, which is widely expressed in a variety of tissues, is a unique member of the S100 protein family. Previous reports showed that S100A13 might be involved in the stress-induced release of some signal peptide-less proteins (such as FGF-1 and IL-1alpha) and also associated with inflammatory functions. It was also reported that S100A13 is a new angiogenesis marker. Here we report the crystal structure of the Ca(2+)-bound form of S100A13 at 2.0 A resolution. S100A13 is a homodimer with four EF-hand motifs in an asymmetric unit, displaying a folding pattern similar to other S100 members. However, S100A13 has the unique structural feature with all alpha-helices being amphiphilic, which was not found in other members of S100s. We propose that this characteristic structure of S100A13 might be related to its ability to mediate the release of FGF-1 and IL-1alpha.
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(as it appears on PubMed at http://www.pubmed.gov), where 17374362 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17374362}}
==About this Structure==
==About this Structure==
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[[Category: Calcium binding protein]]
[[Category: Calcium binding protein]]
[[Category: Metal binding protein]]
[[Category: Metal binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:47:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:32:54 2008''

Revision as of 12:33, 27 July 2008

Image:2h2k.png

Template:STRUCTURE 2h2k

Crystal Structure Analysis of Human S100A13

Template:ABSTRACT PUBMED 17374362

About this Structure

2H2K is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure study on human S100A13 at 2.0 A resolution., Li M, Zhang PF, Pan XW, Chang WR, Biochem Biophys Res Commun. 2007 May 11;356(3):616-21. Epub 2007 Mar 12. PMID:17374362

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