1roa

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{{STRUCTURE_1roa| PDB=1roa | SCENE= }}
{{STRUCTURE_1roa| PDB=1roa | SCENE= }}
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'''Structure of human cystatin D'''
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===Structure of human cystatin D===
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==Overview==
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Cystatins are natural inhibitors of papain-like (family C1) and legumain-related (family C13) cysteine peptidases. Cystatin D is a type 2 cystatin, a secreted inhibitor found in human saliva and tear fluid. Compared with its homologues, cystatin D presents an unusual inhibition profile with a preferential inhibition cathepsin S &gt; cathepsin H &gt; cathepsin L and no inhibition of cathepsin B or pig legumain. To elucidate the structural reasons for this specificity, we have crystallized recombinant human Arg(26)-cystatin D and solved its structures at room temperature and at cryo conditions to 2.5- and 1.8-A resolution, respectively. Human cystatin D presents the typical cystatin fold, with a five-stranded anti-parallel beta-sheet wrapped around a five-turn alpha-helix. The structures reveal differences in the peptidase-interacting regions when compared with other cystatins, providing plausible explanations for the restricted inhibitory specificity of cystatin D for some papain-like peptidases and its lack of reactivity toward legumain-related enzymes.
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The line below this paragraph, {{ABSTRACT_PUBMED_15728581}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15728581 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15728581}}
==About this Structure==
==About this Structure==
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[[Category: Cystatin d]]
[[Category: Cystatin d]]
[[Category: Inhibitor of cysteine pepidase]]
[[Category: Inhibitor of cysteine pepidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:43:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:35:48 2008''

Revision as of 12:35, 27 July 2008

Image:1roa.png

Template:STRUCTURE 1roa

Structure of human cystatin D

Template:ABSTRACT PUBMED 15728581

About this Structure

1ROA is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human cystatin D, a cysteine peptidase inhibitor with restricted inhibition profile., Alvarez-Fernandez M, Liang YH, Abrahamson M, Su XD, J Biol Chem. 2005 May 6;280(18):18221-8. Epub 2005 Feb 23. PMID:15728581

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