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2fe8

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{{STRUCTURE_2fe8| PDB=2fe8 | SCENE= }}
{{STRUCTURE_2fe8| PDB=2fe8 | SCENE= }}
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'''SARS coronavirus papain-like protease: structure of a viral deubiquitinating enzyme'''
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===SARS coronavirus papain-like protease: structure of a viral deubiquitinating enzyme===
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==Overview==
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Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases, a chymotrypsin-like protease (3CLpro) and a papain-like protease (PLpro). These proteases are important targets for development of antiviral drugs that would inhibit viral replication and reduce mortality associated with outbreaks of SARS-CoV. In this work, we describe the 1.85-A crystal structure of the catalytic core of SARS-CoV PLpro and show that the overall architecture adopts a fold closely resembling that of known deubiquitinating enzymes. Key features, however, distinguish PLpro from characterized deubiquitinating enzymes, including an intact zinc-binding motif, an unobstructed catalytically competent active site, and the presence of an intriguing, ubiquitin-like N-terminal domain. To gain insight into the active-site recognition of the C-terminal tail of ubiquitin and the related LXGG motif, we propose a model of PLpro in complex with ubiquitin-aldehyde that reveals well defined sites within the catalytic cleft that help to account for strict substrate-recognition motifs.
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The line below this paragraph, {{ABSTRACT_PUBMED_16581910}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16581910 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16581910}}
==About this Structure==
==About this Structure==
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[[Category: Santarsiero, B D.]]
[[Category: Santarsiero, B D.]]
[[Category: Protease]]
[[Category: Protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:47:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:36:10 2008''

Revision as of 12:36, 27 July 2008

Image:2fe8.png

Template:STRUCTURE 2fe8

SARS coronavirus papain-like protease: structure of a viral deubiquitinating enzyme

Template:ABSTRACT PUBMED 16581910

About this Structure

2FE8 is a Single protein structure of sequence from Sars coronavirus. Full crystallographic information is available from OCA.

Reference

Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme., Ratia K, Saikatendu KS, Santarsiero BD, Barretto N, Baker SC, Stevens RC, Mesecar AD, Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5717-22. Epub 2006 Mar 31. PMID:16581910

Page seeded by OCA on Sun Jul 27 15:36:10 2008

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