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1k79

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(New page: 200px<br /><applet load="1k79" size="450" color="white" frame="true" align="right" spinBox="true" caption="1k79, resolution 2.40&Aring;" /> '''Ets-1(331-440)+GGAA ...)
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Revision as of 16:47, 20 November 2007

Image:1k79.gif

1k79, resolution 2.40Å

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Ets-1(331-440)+GGAA duplex

Overview

Pax5 regulates the B cell-specific expression of the mb-1 gene together, with members of the Ets family of transcriptional activators. The Ets, proteins on their own bind poorly to the Pax5/Ets binding site, but can be, recruited to the site by cooperative interactions with Pax5. The structure, of the ETS domain of Ets-1 and the paired domain of Pax5 bound to DNA, reveals the molecular details of the selective recruitment of different, Ets proteins by Pax5. Comparison with structures of Ets-1 alone bound to, both high- and low-affinity DNA sites reveals that Pax5 alters the Ets-1, contacts with DNA. The ability of one protein to alter the DNA, sequence-specific contacts of another provides a general mechanism for, combinatorial regulation of transcription.

About this Structure

1K79 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural studies of Ets-1/Pax5 complex formation on DNA., Garvie CW, Hagman J, Wolberger C, Mol Cell. 2001 Dec;8(6):1267-76. PMID:11779502

Page seeded by OCA on Tue Nov 20 18:54:44 2007

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