2a0z

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[[Image:2a0z.gif|left|200px]]
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{{Seed}}
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[[Image:2a0z.png|left|200px]]
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{{STRUCTURE_2a0z| PDB=2a0z | SCENE= }}
{{STRUCTURE_2a0z| PDB=2a0z | SCENE= }}
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'''The molecular structure of toll-like receptor 3 ligand binding domain'''
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===The molecular structure of toll-like receptor 3 ligand binding domain===
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==Overview==
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Innate immunity is the first line of defense against invading pathogens. Toll-like receptors (TLRs) act as sentinels of the innate immune system, sensing a variety of ligands from lipopolysaccharide to flagellin to dsRNA through their ligand-binding domain that is composed of leucine-rich repeats (LRRs). Ligand binding initiates a signaling cascade that leads to the up-regulation of inflammation mediators. In this study, we have expressed and crystallized the ectodomain (ECD) of human TLR3, which recognizes dsRNA, a molecular signature of viruses, and have determined the molecular structure to 2.4-A resolution. The overall horseshoe-shaped structure of the TLR3-ECD is formed by 23 repeating LRRs that are capped at each end by specialized non-LRR domains. The extensive beta-sheet on the molecule's concave surface forms a platform for several modifications, including insertions in the LRRs and 11 N-linked glycans. The TLR3-ECD structure indicates how LRR loops can establish distinct pathogen recognition receptors.
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The line below this paragraph, {{ABSTRACT_PUBMED_16043704}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16043704 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16043704}}
==About this Structure==
==About this Structure==
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[[Category: Leucine rich repeat]]
[[Category: Leucine rich repeat]]
[[Category: Solenoid]]
[[Category: Solenoid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:28:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:39:05 2008''

Revision as of 12:39, 27 July 2008

Image:2a0z.png

Template:STRUCTURE 2a0z

The molecular structure of toll-like receptor 3 ligand binding domain

Template:ABSTRACT PUBMED 16043704

About this Structure

2A0Z is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The molecular structure of the Toll-like receptor 3 ligand-binding domain., Bell JK, Botos I, Hall PR, Askins J, Shiloach J, Segal DM, Davies DR, Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10976-80. Epub 2005 Jul 25. PMID:16043704

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