2h8a

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{{STRUCTURE_2h8a| PDB=2h8a | SCENE= }}
{{STRUCTURE_2h8a| PDB=2h8a | SCENE= }}
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'''Structure of Microsomal Glutathione Transferase 1 in Complex with Glutathione'''
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===Structure of Microsomal Glutathione Transferase 1 in Complex with Glutathione===
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==Overview==
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Synthesis of mediators of fever, pain and inflammation as well as protection against reactive molecules and oxidative stress is a hallmark of the MAPEG superfamily (membrane associated proteins in eicosanoid and glutathione metabolism). The structure of a MAPEG member, rat microsomal glutathione transferase 1, at 3.2 A resolution, solved here in complex with glutathione by electron crystallography, defines the active site location and a cytosolic domain involved in enzyme activation. The glutathione binding site is found to be different from that of the canonical soluble glutathione transferases. The architecture of the homotrimer supports a catalytic mechanism involving subunit interactions and reveals both cytosolic and membraneous substrate entry sites, providing a rationale for the membrane location of the enzyme.
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(as it appears on PubMed at http://www.pubmed.gov), where 16806268 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16806268}}
==About this Structure==
==About this Structure==
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[[Category: Hebert, H.]]
[[Category: Hebert, H.]]
[[Category: Membrane protein]]
[[Category: Membrane protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:59:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:42:36 2008''

Revision as of 12:42, 27 July 2008

Image:2h8a.png

Template:STRUCTURE 2h8a

Structure of Microsomal Glutathione Transferase 1 in Complex with Glutathione

Template:ABSTRACT PUBMED 16806268

About this Structure

2H8A is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structural basis for detoxification and oxidative stress protection in membranes., Holm PJ, Bhakat P, Jegerschold C, Gyobu N, Mitsuoka K, Fujiyoshi Y, Morgenstern R, Hebert H, J Mol Biol. 2006 Jul 28;360(5):934-45. Epub 2006 Jun 5. PMID:16806268

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