2zat

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{{STRUCTURE_2zat| PDB=2zat | SCENE= }}
{{STRUCTURE_2zat| PDB=2zat | SCENE= }}
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'''Crystal structure of a mammalian reductase'''
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===Crystal structure of a mammalian reductase===
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==Overview==
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Pig heart peroxisomal carbonyl reductase (PerCR) belongs to the short-chain dehydrogenase/reductase family, and its sequence comprises a C-terminal SRL tripeptide, which is a variant of the type 1 peroxisomal targeting signal (PTS1) Ser-Lys-Leu. PerCR is imported into peroxisomes of HeLa cells when the cells are transfected with vectors expressing the enzyme. However, PerCR does not show specific targeting when introduced into the cells with a protein transfection reagent. To understand the structural basis for peroxisomal localization of PerCR, we determined the crystal structure of PerCR. Our data revealed that the C-terminal PTS1 of each subunit of PerCR was involved in intersubunit interactions and was buried in the interior of the tetrameric molecule. These findings indicate that the PTS1 receptor Pex5p in the cytosol recognizes the monomeric form of PerCR whose C-terminal PTS1 is exposed, and that this PerCR is targeted into the peroxisome, thereby forming a tetramer.
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(as it appears on PubMed at http://www.pubmed.gov), where 18334214 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18334214}}
==About this Structure==
==About this Structure==
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[[Category: Alpha/beta]]
[[Category: Alpha/beta]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:30:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:46:12 2008''

Revision as of 12:46, 27 July 2008

Image:2zat.png

Template:STRUCTURE 2zat

Crystal structure of a mammalian reductase

Template:ABSTRACT PUBMED 18334214

About this Structure

2ZAT is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Molecular basis for peroxisomal localization of tetrameric carbonyl reductase., Tanaka N, Aoki K, Ishikura S, Nagano M, Imamura Y, Hara A, Nakamura KT, Structure. 2008 Mar;16(3):388-97. PMID:18334214

Page seeded by OCA on Sun Jul 27 15:46:12 2008

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