1wlh

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[[Image:1wlh.jpg|left|200px]]
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{{STRUCTURE_1wlh| PDB=1wlh | SCENE= }}
{{STRUCTURE_1wlh| PDB=1wlh | SCENE= }}
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'''Molecular structure of the rod domain of Dictyostelium filamin'''
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===Molecular structure of the rod domain of Dictyostelium filamin===
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==Overview==
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Dictyostelium discoideum filamin (ddFLN) is a two-chain F-actin crosslinking protein with an N-terminal actin-binding domain and a rod domain constructed from six tandem repeats of a 100 residue motif that has an immunoglobulin (Ig) fold. We report the 2.8 A resolution crystal structure of a homodimer of rod repeats 4, 5 and 6. The two chains are arranged in an antiparallel fashion and form an elongated element, which is shortened, however, compared to a fully extended, linear configuration because the long axis of each Ig domain is arranged at an angle to the long axis of the rod. Same arrangement of repeats should also be present in the rod domain of human FLNa, much longer than Dictyostelium FLN, which forms an extended structure able to crosslink F-actin chains over distances of more than 1000 A.
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(as it appears on PubMed at http://www.pubmed.gov), where 15364587 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15364587}}
==About this Structure==
==About this Structure==
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[[Category: Immunoglobulin fold]]
[[Category: Immunoglobulin fold]]
[[Category: Rod domain]]
[[Category: Rod domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:50:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:49:20 2008''

Revision as of 12:49, 27 July 2008

Image:1wlh.png

Template:STRUCTURE 1wlh

Molecular structure of the rod domain of Dictyostelium filamin

Template:ABSTRACT PUBMED 15364587

About this Structure

1WLH is a Single protein structure of sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.

Reference

Molecular structure of the rod domain of dictyostelium filamin., Popowicz GM, Muller R, Noegel AA, Schleicher M, Huber R, Holak TA, J Mol Biol. 2004 Oct 1;342(5):1637-46. PMID:15364587

Page seeded by OCA on Sun Jul 27 15:49:20 2008

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