1sor

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[[Image:1sor.gif|left|200px]]
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{{Seed}}
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[[Image:1sor.png|left|200px]]
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{{STRUCTURE_1sor| PDB=1sor | SCENE= }}
{{STRUCTURE_1sor| PDB=1sor | SCENE= }}
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'''Aquaporin-0 membrane junctions reveal the structure of a closed water pore'''
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===Aquaporin-0 membrane junctions reveal the structure of a closed water pore===
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==Overview==
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The lens-specific water pore aquaporin-0 (AQP0) is the only aquaporin known to form membrane junctions in vivo. We show here that AQP0 from the lens core, containing some carboxy-terminally cleaved AQP0, forms double-layered crystals that recapitulate in vivo junctions. We present the structure of the AQP0 membrane junction as determined by electron crystallography. The junction is formed by three localized interactions between AQP0 molecules in adjoining membranes, mainly mediated by proline residues conserved in AQP0s from different species but not present in most other aquaporins. Whereas all previously determined aquaporin structures show the pore in an open conformation, the water pore is closed in AQP0 junctions. The water pathway in AQP0 also contains an additional pore constriction, not seen in other known aquaporin structures, which may be responsible for pore gating.
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The line below this paragraph, {{ABSTRACT_PUBMED_15141214}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15141214 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15141214}}
==About this Structure==
==About this Structure==
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[[Category: Membrane junction]]
[[Category: Membrane junction]]
[[Category: Water channel]]
[[Category: Water channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:57:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:51:27 2008''

Revision as of 12:51, 27 July 2008

Image:1sor.png

Template:STRUCTURE 1sor

Aquaporin-0 membrane junctions reveal the structure of a closed water pore

Template:ABSTRACT PUBMED 15141214

About this Structure

1SOR is a Single protein structure of sequence from Ovis aries. Full crystallographic information is available from OCA.

Reference

Aquaporin-0 membrane junctions reveal the structure of a closed water pore., Gonen T, Sliz P, Kistler J, Cheng Y, Walz T, Nature. 2004 May 13;429(6988):193-7. PMID:15141214

Page seeded by OCA on Sun Jul 27 15:51:27 2008

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