1rla

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1rla.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1rla.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1rla| PDB=1rla | SCENE= }}
{{STRUCTURE_1rla| PDB=1rla | SCENE= }}
-
'''THREE-DIMENSIONAL STRUCTURE OF RAT LIVER ARGINASE, THE BINUCLEAR MANGANESE METALLOENZYME OF THE UREA CYCLE'''
+
===THREE-DIMENSIONAL STRUCTURE OF RAT LIVER ARGINASE, THE BINUCLEAR MANGANESE METALLOENZYME OF THE UREA CYCLE===
-
==Overview==
+
<!--
-
Each individual excretes roughly 10 kg of urea per year, as a result of the hydrolysis of arginine in the final cytosolic step of the urea cycle. This reaction allows the disposal of nitrogenous waste from protein catabolism, and is catalysed by the liver arginase enzyme. In other tissues that lack a complete urea cycle, arginase regulates cellular arginine and ornithine concentrations for biosynthetic reactions, including nitric oxide synthesis: in the macrophage, arginase activity is reciprocally coordinated with that of NO synthase to modulate NO-dependent cytotoxicity. The bioinorganic chemistry of arginase is particularly rich because this enzyme is one of very few that specifically requires a spin-coupled Mn2+-Mn2+ cluster for catalytic activity in vitro and in vivo. The 2.1 angstrom-resolution crystal structure of trimeric rat liver arginase reveals that this unique metal cluster resides at the bottom of an active-site cleft that is 15 angstroms deep. Analysis of the structure indicates that arginine hydrolysis is achieved by a metal-activated solvent molecule which symmetrically bridges the two Mn2+ ions.
+
The line below this paragraph, {{ABSTRACT_PUBMED_8849731}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 8849731 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_8849731}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Magnesium]]
[[Category: Magnesium]]
[[Category: Urea cycle]]
[[Category: Urea cycle]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:38:15 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:53:24 2008''

Revision as of 12:53, 27 July 2008

Image:1rla.png

Template:STRUCTURE 1rla

THREE-DIMENSIONAL STRUCTURE OF RAT LIVER ARGINASE, THE BINUCLEAR MANGANESE METALLOENZYME OF THE UREA CYCLE

Template:ABSTRACT PUBMED 8849731

About this Structure

1RLA is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of a unique binuclear manganese cluster in arginase., Kanyo ZF, Scolnick LR, Ash DE, Christianson DW, Nature. 1996 Oct 10;383(6600):554-7. PMID:8849731

Page seeded by OCA on Sun Jul 27 15:53:24 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1rla"
Personal tools