1k8i
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(New page: 200px<br /><applet load="1k8i" size="450" color="white" frame="true" align="right" spinBox="true" caption="1k8i, resolution 3.10Å" /> '''CRYSTAL STRUCTURE OF...)
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Revision as of 16:50, 20 November 2007
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CRYSTAL STRUCTURE OF MOUSE H2-DM
Overview
H2-M (HLA-DM in humans) resides in an acidic endosomal compartment, where, it facilitates the loading of antigenic peptides into the peptide-binding, groove of class II MHC. The crystal structure of a soluble form of H2-M, has been solved to 3.1 A resolution, revealing a heterodimer with, structural similarities to the MHC family of proteins. In contrast to its, antigen-presenting cousins, the membrane distal alpha helices of H2-M pack, closely together, occluding most of the binding groove except for a single, large pocket near the center. The structure of H2-M has several unique, features that may play a role in its function as a molecular chaperone and, peptide exchange factor.
About this Structure
1K8I is a Protein complex structure of sequences from Mus musculus with NAG as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of mouse H2-M., Fremont DH, Crawford F, Marrack P, Hendrickson WA, Kappler J, Immunity. 1998 Sep;9(3):385-93. PMID:9768758
Page seeded by OCA on Tue Nov 20 18:57:15 2007
