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1rfr

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{{STRUCTURE_1rfr| PDB=1rfr | SCENE= }}
{{STRUCTURE_1rfr| PDB=1rfr | SCENE= }}
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'''NMR structure of the 30mer stemloop-D of coxsackieviral RNA'''
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===NMR structure of the 30mer stemloop-D of coxsackieviral RNA===
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==Overview==
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Stemloop D (SLD) of the 5' cloverleaf RNA is the cognate ligand of the coxsackievirus B3 (CVB3) 3C proteinase (3Cpro). Both are indispensable components of the viral replication initiation complex. SLD is a structurally autonomous subunit of the 5' cloverleaf. The SLD structure was solved by NMR spectroscopy to an rms deviation of 0.66 A (all heavy atoms). SLD contains a novel triple pyrimidine mismatch motif with a central Watson-Crick type C:U pair. SLD is capped by an apical uCACGg tetraloop adopting a structure highly similar to stable cUNCGg tetraloops. Binding of CVB3 3Cpro induces changes in NMR spectra for nucleotides adjacent to the triple pyrimidine mismatch and of the tetraloop implying them as sites of specific SLD:3Cpro interaction. The binding of 3Cpro to SLD requires the integrity of those structural elements, strongly suggesting that 3Cpro recognizes a structural motif instead of a specific sequence.
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(as it appears on PubMed at http://www.pubmed.gov), where 14962384 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14962384}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RFR OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RFR OCA].
==Reference==
==Reference==
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[[Category: Base-paired u:u-c:u-u:u mismatch]]
[[Category: Base-paired u:u-c:u-u:u mismatch]]
[[Category: Loop with conformation similar to stable uncg-tetraloops and u:g closing base pair]]
[[Category: Loop with conformation similar to stable uncg-tetraloops and u:g closing base pair]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:26:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:58:34 2008''

Revision as of 12:58, 27 July 2008

Image:1rfr.png

Template:STRUCTURE 1rfr

NMR structure of the 30mer stemloop-D of coxsackieviral RNA

Template:ABSTRACT PUBMED 14962384

About this Structure

Full experimental information is available from OCA.

Reference

The structure of the stemloop D subdomain of coxsackievirus B3 cloverleaf RNA and its interaction with the proteinase 3C., Ohlenschlager O, Wohnert J, Bucci E, Seitz S, Hafner S, Ramachandran R, Zell R, Gorlach M, Structure. 2004 Feb;12(2):237-48. PMID:14962384

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