2a9i

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[[Image:2a9i.gif|left|200px]]
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{{STRUCTURE_2a9i| PDB=2a9i | SCENE= }}
{{STRUCTURE_2a9i| PDB=2a9i | SCENE= }}
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'''Molecular Structure of the Interleukin-1 Receptor-Associated Kinase-4 Death Domain'''
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===Molecular Structure of the Interleukin-1 Receptor-Associated Kinase-4 Death Domain===
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==Overview==
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IL-1R-associated kinase (IRAK) 4 is an essential component of innate immunity. IRAK-4 deficiency in mice and humans results in severe impairment of IL-1 and TLR signaling. We have solved the crystal structure for the death domain of Mus musculus IRAK-4 to 1.7 A resolution. This is the first glimpse of the structural details of a mammalian IRAK family member. The crystal structure reveals a six-helical bundle with a prominent loop, which among IRAKs and Pelle, a Drosophila homologue, is unique to IRAK-4. This highly structured loop contained between helices two and three, comprises an 11-aa stretch. Although innate immune domain recognition is thought to be very similar between Drosophila and mammals, this structural component points to a drastic difference. This structure can be used as a framework for future mutation and deletion studies and potential drug design.
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(as it appears on PubMed at http://www.pubmed.gov), where 16177054 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16177054}}
==About this Structure==
==About this Structure==
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[[Category: Nair, S K.]]
[[Category: Nair, S K.]]
[[Category: Hexahelical bundle]]
[[Category: Hexahelical bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:46:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:58:59 2008''

Revision as of 12:59, 27 July 2008

Image:2a9i.png

Template:STRUCTURE 2a9i

Molecular Structure of the Interleukin-1 Receptor-Associated Kinase-4 Death Domain

Template:ABSTRACT PUBMED 16177054

About this Structure

2A9I is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Cutting edge: molecular structure of the IL-1R-associated kinase-4 death domain and its implications for TLR signaling., Lasker MV, Gajjar MM, Nair SK, J Immunol. 2005 Oct 1;175(7):4175-9. PMID:16177054

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