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1yjd

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{{STRUCTURE_1yjd| PDB=1yjd | SCENE= }}
{{STRUCTURE_1yjd| PDB=1yjd | SCENE= }}
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'''Crystal structure of human CD28 in complex with the Fab fragment of a mitogenic antibody (5.11A1)'''
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===Crystal structure of human CD28 in complex with the Fab fragment of a mitogenic antibody (5.11A1)===
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==Overview==
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Naive T cell activation requires signaling by the T cell receptor and by nonclonotypic cell surface receptors. The most important costimulatory protein is the monovalent homodimer CD28, which interacts with CD80 and CD86 expressed on antigen-presenting cells. Here we present the crystal structure of a soluble form of CD28 in complex with the Fab fragment of a mitogenic antibody. Structural comparisons redefine the evolutionary relationships of CD28-related proteins, antigen receptors and adhesion molecules and account for the distinct ligand-binding and stoichiometric properties of CD28 and the related, inhibitory homodimer CTLA-4. Cryo-electron microscopy-based comparisons of complexes of CD28 with mitogenic and nonmitogenic antibodies place new constraints on models of antibody-induced receptor triggering. This work completes the initial structural characterization of the CD28-CTLA-4-CD80-CD86 signaling system.
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(as it appears on PubMed at http://www.pubmed.gov), where 15696168 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15696168}}
==About this Structure==
==About this Structure==
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[[Category: Cd28 homodimer]]
[[Category: Cd28 homodimer]]
[[Category: Igsf]]
[[Category: Igsf]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:23:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:04:30 2008''

Revision as of 13:04, 27 July 2008

Image:1yjd.png

Template:STRUCTURE 1yjd

Crystal structure of human CD28 in complex with the Fab fragment of a mitogenic antibody (5.11A1)

Template:ABSTRACT PUBMED 15696168

About this Structure

1YJD is a Single protein structure of sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a soluble CD28-Fab complex., Evans EJ, Esnouf RM, Manso-Sancho R, Gilbert RJ, James JR, Yu C, Fennelly JA, Vowles C, Hanke T, Walse B, Hunig T, Sorensen P, Stuart DI, Davis SJ, Nat Immunol. 2005 Mar;6(3):271-9. Epub 2005 Feb 6. PMID:15696168

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