2nrf

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{{STRUCTURE_2nrf| PDB=2nrf | SCENE= }}
{{STRUCTURE_2nrf| PDB=2nrf | SCENE= }}
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'''Crystal Structure of GlpG, a Rhomboid family intramembrane protease'''
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===Crystal Structure of GlpG, a Rhomboid family intramembrane protease===
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==Overview==
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Intramembrane proteolysis regulates diverse biological processes. Cleavage of substrate peptide bonds within the membrane bilayer is catalyzed by integral membrane proteases. Here we report the crystal structure of the transmembrane core domain of GlpG, a rhomboid-family intramembrane serine protease from Escherichia coli. The protein contains six transmembrane helices, with the catalytic Ser201 located at the N terminus of helix alpha4 approximately 10 A below the membrane surface. Access to water molecules is provided by a central cavity that opens to the extracellular region and converges on Ser201. One of the two GlpG molecules in the asymmetric unit has an open conformation at the active site, with the transmembrane helix alpha5 bent away from the rest of the molecule. Structural analysis suggests that substrate entry to the active site is probably gated by the movement of helix alpha5.
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(as it appears on PubMed at http://www.pubmed.gov), where 17099694 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17099694}}
==About this Structure==
==About this Structure==
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[[Category: Yan, N.]]
[[Category: Yan, N.]]
[[Category: Integral membrane protein]]
[[Category: Integral membrane protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:49:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:06:19 2008''

Revision as of 13:06, 27 July 2008

Image:2nrf.png

Template:STRUCTURE 2nrf

Crystal Structure of GlpG, a Rhomboid family intramembrane protease

Template:ABSTRACT PUBMED 17099694

About this Structure

2NRF is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry., Wu Z, Yan N, Feng L, Oberstein A, Yan H, Baker RP, Gu L, Jeffrey PD, Urban S, Shi Y, Nat Struct Mol Biol. 2006 Dec;13(12):1084-91. Epub 2006 Nov 10. PMID:17099694

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