2iij

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[[Image:2iij.jpg|left|200px]]
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{{Seed}}
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[[Image:2iij.png|left|200px]]
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{{STRUCTURE_2iij| PDB=2iij | SCENE= }}
{{STRUCTURE_2iij| PDB=2iij | SCENE= }}
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'''Structure of human Asf1a in complex with histone H3'''
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===Structure of human Asf1a in complex with histone H3===
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==Overview==
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Asf1 is a histone chaperone that favors histone H3/H4 assembly and disassembly. We solved the structure of the conserved domain of human ASF1A in complex with the C-terminal helix of histone H3 using nuclear magnetic resonance spectroscopy. This structure is fully compatible with an association of ASF1 with the heterodimeric form of histones H3/H4. In our model, ASF1 substitutes for the second H3/H4 heterodimer that is normally found in heterotetrameric H3/H4 complexes. This result constitutes an essential step in the fundamental understanding of the mechanisms of nucleosome assembly by histone chaperones. Point mutations that perturb the Asf1/histone interface were designed from the structure. The decreased binding affinity of the Asf1-H3/H4 complex correlates with decreased levels of H3-K56 acetylation and phenotypic defects in vivo.
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(as it appears on PubMed at http://www.pubmed.gov), where 17292837 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17292837}}
==About this Structure==
==About this Structure==
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2IIJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IIJ OCA].
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2IIJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IIJ OCA].
==Reference==
==Reference==
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[[Category: Ochsenbein, F.]]
[[Category: Ochsenbein, F.]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:32:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:07:43 2008''

Revision as of 13:07, 27 July 2008

Image:2iij.png

Template:STRUCTURE 2iij

Structure of human Asf1a in complex with histone H3

Template:ABSTRACT PUBMED 17292837

About this Structure

2IIJ is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure of the histone chaperone ASF1 bound to the histone H3 C-terminal helix and functional insights., Agez M, Chen J, Guerois R, van Heijenoort C, Thuret JY, Mann C, Ochsenbein F, Structure. 2007 Feb;15(2):191-9. PMID:17292837

Page seeded by OCA on Sun Jul 27 16:07:43 2008

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