2tps

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[[Image:2tps.gif|left|200px]]
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{{Seed}}
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[[Image:2tps.png|left|200px]]
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{{STRUCTURE_2tps| PDB=2tps | SCENE= }}
{{STRUCTURE_2tps| PDB=2tps | SCENE= }}
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'''THIAMIN PHOSPHATE SYNTHASE'''
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===THIAMIN PHOSPHATE SYNTHASE===
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==Overview==
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The characterization of a three-gene operon (the thiC operon) at 331 min, which is involved in thiamine biosynthesis in Bacillus subtilis, is described. The first gene in the operon is homologous to transcription activators in the lysR family. The second and third genes (thiK and thiC) have been subcloned and overexpressed in Escherichia coli. ThiK (30 kDa) catalyzes the phosphorylation of 4-methyl-5-(beta-hydroxyethyl)thiazole. ThiC (27 kDa) catalyzes the substitution of the pyrophosphate of 2-methyl-4-amino-5-hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-(beta-hydroxyethyl)thiazole phosphate to yield thiamine phosphate. Transcription of the thiC operon is not regulated by thiamine or 2-methyl-4-amino-5-hydroxymethylpyrimidine and is only slightly repressed by 4-methyl-5-(beta-hydroxyethyl)thiazole.
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(as it appears on PubMed at http://www.pubmed.gov), where 9139923 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9139923}}
==About this Structure==
==About this Structure==
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[[Category: Thiamin biosynthesis]]
[[Category: Thiamin biosynthesis]]
[[Category: Tim barrel]]
[[Category: Tim barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:25:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:08:57 2008''

Revision as of 13:09, 27 July 2008

Image:2tps.png

Template:STRUCTURE 2tps

THIAMIN PHOSPHATE SYNTHASE

Template:ABSTRACT PUBMED 9139923

About this Structure

2TPS is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Characterization of the Bacillus subtilis thiC operon involved in thiamine biosynthesis., Zhang Y, Taylor SV, Chiu HJ, Begley TP, J Bacteriol. 1997 May;179(9):3030-5. PMID:9139923

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