1sjj

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[[Image:1sjj.gif|left|200px]]
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{{STRUCTURE_1sjj| PDB=1sjj | SCENE= }}
{{STRUCTURE_1sjj| PDB=1sjj | SCENE= }}
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'''Cryo-EM Structure of Chicken Gizzard Smooth Muscle alpha-Actinin'''
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===Cryo-EM Structure of Chicken Gizzard Smooth Muscle alpha-Actinin===
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==Overview==
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Cryoelectron microscopy was used to obtain a 3-D image at 2.0 nm resolution of 2-D arrays of smooth muscle alpha-actinin. The reconstruction reveals a well-resolved long central domain with 90 degrees of left-handed twist and near 2-fold symmetry. However, the molecular ends which contain the actin binding and calmodulin-like domains, have different structures oriented approximately 90 degrees to each other. Atomic structures for the alpha-actinin domains were built by homology modeling and assembled into an atomic model. Model building suggests that in the 2-D arrays, the two calponin homology domains that comprise the actin-binding domain have a closed conformation at one end and an open conformation at the other end due to domain swapping. The open and closed conformations of the actin-binding domain suggests flexibility that may underlie Ca2+ regulation. The approximately 90 degrees orientation difference at the molecular ends may underlie alpha-actinin's ability to crosslink actin filaments in nearly any orientation.
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The line below this paragraph, {{ABSTRACT_PUBMED_15050827}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15050827 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15050827}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
A 3-D reconstruction of smooth muscle alpha-actinin by CryoEm reveals two different conformations at the actin-binding region., Liu J, Taylor DW, Taylor KA, J Mol Biol. 2004 Apr 16;338(1):115-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15050827 15050827]
A 3-D reconstruction of smooth muscle alpha-actinin by CryoEm reveals two different conformations at the actin-binding region., Liu J, Taylor DW, Taylor KA, J Mol Biol. 2004 Apr 16;338(1):115-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15050827 15050827]
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Projection image of smooth muscle alpha-actinin from two-dimensional crystals formed on positively charged lipid layers., Taylor KA, Taylor DW, J Mol Biol. 1993 Mar 5;230(1):196-205. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8450536 8450536]
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The three-dimensional structure of alpha-actinin obtained by cryoelectron microscopy suggests a model for Ca(2+)-dependent actin binding., Tang J, Taylor DW, Taylor KA, J Mol Biol. 2001 Jul 20;310(4):845-58. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11453692 11453692]
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Isoforms of alpha-actinin from cardiac, smooth, and skeletal muscle form polar arrays of actin filaments., Taylor KA, Taylor DW, Schachat F, J Cell Biol. 2000 May 1;149(3):635-46. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10791977 10791977]
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Calmodulin-like domain]]
[[Category: Calmodulin-like domain]]
[[Category: Calponin homology domain]]
[[Category: Calponin homology domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:46:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:10:06 2008''

Revision as of 13:10, 27 July 2008

Image:1sjj.png

Template:STRUCTURE 1sjj

Cryo-EM Structure of Chicken Gizzard Smooth Muscle alpha-Actinin

Template:ABSTRACT PUBMED 15050827

About this Structure

1SJJ is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

A 3-D reconstruction of smooth muscle alpha-actinin by CryoEm reveals two different conformations at the actin-binding region., Liu J, Taylor DW, Taylor KA, J Mol Biol. 2004 Apr 16;338(1):115-25. PMID:15050827

Projection image of smooth muscle alpha-actinin from two-dimensional crystals formed on positively charged lipid layers., Taylor KA, Taylor DW, J Mol Biol. 1993 Mar 5;230(1):196-205. PMID:8450536

The three-dimensional structure of alpha-actinin obtained by cryoelectron microscopy suggests a model for Ca(2+)-dependent actin binding., Tang J, Taylor DW, Taylor KA, J Mol Biol. 2001 Jul 20;310(4):845-58. PMID:11453692

Isoforms of alpha-actinin from cardiac, smooth, and skeletal muscle form polar arrays of actin filaments., Taylor KA, Taylor DW, Schachat F, J Cell Biol. 2000 May 1;149(3):635-46. PMID:10791977

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