1ry6

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{{STRUCTURE_1ry6| PDB=1ry6 | SCENE= }}
{{STRUCTURE_1ry6| PDB=1ry6 | SCENE= }}
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'''Crystal Structure of Internal Kinesin Motor Domain'''
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===Crystal Structure of Internal Kinesin Motor Domain===
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==Overview==
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With their ability to depolymerize microtubules (MTs), KinI kinesins are the rogue members of the kinesin family. Here we present the 1.6 A crystal structure of a KinI motor core from Plasmodium falciparum, which is sufficient for depolymerization in vitro. Unlike all published kinesin structures to date, nucleotide is not present, and there are noticeable differences in loop regions L6 and L10 (the plus-end tip), L2 and L8 and in switch II (L11 and helix4); otherwise, the pKinI structure is very similar to previous kinesin structures. KinI-conserved amino acids were mutated to alanine, and studied for their effects on depolymerization and ATP hydrolysis. Notably, mutation of three residues in L2 appears to primarily affect depolymerization, rather than general MT binding or ATP hydrolysis. The results of this study confirm the suspected importance of loop 2 for KinI function, and provide evidence that KinI is specialized to hydrolyze ATP after initiating depolymerization.
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(as it appears on PubMed at http://www.pubmed.gov), where 15029249 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15029249}}
==About this Structure==
==About this Structure==
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[[Category: Kinesin motor domain]]
[[Category: Kinesin motor domain]]
[[Category: Nucleotide-free]]
[[Category: Nucleotide-free]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:03:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:12:02 2008''

Revision as of 13:12, 27 July 2008

Image:1ry6.png

Template:STRUCTURE 1ry6

Crystal Structure of Internal Kinesin Motor Domain

Template:ABSTRACT PUBMED 15029249

About this Structure

1RY6 is a Single protein structure of sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.

Reference

Structure of a kinesin microtubule depolymerization machine., Shipley K, Hekmat-Nejad M, Turner J, Moores C, Anderson R, Milligan R, Sakowicz R, Fletterick R, EMBO J. 2004 Apr 7;23(7):1422-32. Epub 2004 Mar 18. PMID:15029249

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