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1old

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{{STRUCTURE_1old| PDB=1old | SCENE= }}
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'''NMR STRUCTURE OF 24-MER DEOXYRIBONUCLEIC ACID, 7 STRUCTURES'''
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===NMR STRUCTURE OF 24-MER DEOXYRIBONUCLEIC ACID, 7 STRUCTURES===
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==Overview==
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Here we present the first solution structure of a ligand-DNA aptamer complex. Our NMR-molecular dynamics structural studies of the interaction between argininamide and a DNA stem-loop complex establishes that the hairpin loop DNA binding site undergoes an adaptive conformational transition on complex formation. The tip of the DNA loop folds down towards the stem and sandwiches the bound argininamide between reversed Hoogsteen A.C and Watson-Crick G.C base pairs. The argininamide is encapsulated within the structured DNA loop and is stabilized by an intricate set of intermolecular hydrogen bonds and stacking interactions. The structure of the complex lays out the molecular principles defining both the architecture of the internal cavity and the recognition elements that could contribute to ligand discrimination.
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(as it appears on PubMed at http://www.pubmed.gov), where 8946859 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8946859}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OLD OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OLD OCA].
==Reference==
==Reference==
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[[Category: Deoxyribonucleic acid]]
[[Category: Deoxyribonucleic acid]]
[[Category: Dna]]
[[Category: Dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:59:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:12:26 2008''

Revision as of 13:12, 27 July 2008

Image:1old.png

Template:STRUCTURE 1old

NMR STRUCTURE OF 24-MER DEOXYRIBONUCLEIC ACID, 7 STRUCTURES

Template:ABSTRACT PUBMED 8946859

About this Structure

Full experimental information is available from OCA.

Reference

Encapsulating an amino acid in a DNA fold., Lin CH, Patel DJ, Nat Struct Biol. 1996 Dec;3(12):1046-50. PMID:8946859

Page seeded by OCA on Sun Jul 27 16:12:26 2008

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