1zbd

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{{STRUCTURE_1zbd| PDB=1zbd | SCENE= }}
{{STRUCTURE_1zbd| PDB=1zbd | SCENE= }}
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'''STRUCTURAL BASIS OF RAB EFFECTOR SPECIFICITY: CRYSTAL STRUCTURE OF THE SMALL G PROTEIN RAB3A COMPLEXED WITH THE EFFECTOR DOMAIN OF RABPHILIN-3A'''
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===STRUCTURAL BASIS OF RAB EFFECTOR SPECIFICITY: CRYSTAL STRUCTURE OF THE SMALL G PROTEIN RAB3A COMPLEXED WITH THE EFFECTOR DOMAIN OF RABPHILIN-3A===
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==Overview==
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The small G protein Rab3A plays an important role in the regulation of neurotransmitter release. The crystal structure of activated Rab3A/GTP/Mg2+ bound to the effector domain of rabphilin-3A was solved to 2.6 A resolution. Rabphilin-3A contacts Rab3A in two distinct areas. The first interface involves the Rab3A switch I and switch II regions, which are sensitive to the nucleotide-binding state of Rab3A. The second interface consists of a deep pocket in Rab3A that interacts with a SGAWFF structural element of rabphilin-3A. Sequence and structure analysis, and biochemical data suggest that this pocket, or Rab complementarity-determining region (RabCDR), establishes a specific interaction between each Rab protein and its effectors. RabCDRs could be major determinants of effector specificity during vesicle trafficking and fusion.
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(as it appears on PubMed at http://www.pubmed.gov), where 10025402 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10025402}}
==About this Structure==
==About this Structure==
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[[Category: Rabphilin]]
[[Category: Rabphilin]]
[[Category: Synaptic exocytosis]]
[[Category: Synaptic exocytosis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:25:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:15:54 2008''

Revision as of 13:15, 27 July 2008

Image:1zbd.png

Template:STRUCTURE 1zbd

STRUCTURAL BASIS OF RAB EFFECTOR SPECIFICITY: CRYSTAL STRUCTURE OF THE SMALL G PROTEIN RAB3A COMPLEXED WITH THE EFFECTOR DOMAIN OF RABPHILIN-3A

Template:ABSTRACT PUBMED 10025402

About this Structure

1ZBD is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A., Ostermeier C, Brunger AT, Cell. 1999 Feb 5;96(3):363-74. PMID:10025402

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