1pfz

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{{STRUCTURE_1pfz| PDB=1pfz | SCENE= }}
{{STRUCTURE_1pfz| PDB=1pfz | SCENE= }}
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'''PROPLASMEPSIN II FROM PLASMODIUM FALCIPARUM'''
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===PROPLASMEPSIN II FROM PLASMODIUM FALCIPARUM===
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==Overview==
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Proplasmepsin II is the zymogen of plasmepsin II, an aspartic proteinase used by Plasmodiumfalciparum to digest hemoglobin during the blood stage of malaria. A large shift between the N-domain and the central and C-domains of proplasmepsin II opens the active site cleft, preventing the formation of a functional aspartic proteinase active site. This mode of inhibition of catalytic activity has not been observed in any other aspartic proteinase zymogen. Instead of occluding a pre-formed active site, as in the gastric aspartic proteinase zymogens, the prosegment of proplasmepsin II interacts extensively with the C-domain and serves as a 'harness' to keep the domains apart. Disruption of key salt bridges at low pH may be important in activation.
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(as it appears on PubMed at http://www.pubmed.gov), where 9886289 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9886289}}
==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Malaria]]
[[Category: Malaria]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:02:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:20:52 2008''

Revision as of 13:20, 27 July 2008

Image:1pfz.png

Template:STRUCTURE 1pfz

PROPLASMEPSIN II FROM PLASMODIUM FALCIPARUM

Template:ABSTRACT PUBMED 9886289

About this Structure

1PFZ is a Single protein structure of sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.

Reference

Crystal structure of the novel aspartic proteinase zymogen proplasmepsin II from plasmodium falciparum., Bernstein NK, Cherney MM, Loetscher H, Ridley RG, James MN, Nat Struct Biol. 1999 Jan;6(1):32-7. PMID:9886289

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