1qyg

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{{Seed}}
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{{STRUCTURE_1qyg| PDB=1qyg | SCENE= }}
{{STRUCTURE_1qyg| PDB=1qyg | SCENE= }}
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'''ANTI-COCAINE ANTIBODY M82G2 COMPLEXED WITH BENZOYLECGONINE'''
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===ANTI-COCAINE ANTIBODY M82G2 COMPLEXED WITH BENZOYLECGONINE===
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==Overview==
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Antibodies against cocaine and other drugs of abuse are the basis for diagnostic tests for the presence of those drugs in human serum. The 1.7A resolution crystal structure of the anti-cocaine monoclonal antibody M82G2 in complex with cocaine is presented. This structure determination was undertaken to establish the stereochemical features in the antibody binding site that confer specificity for cocaine, and as part of an ongoing project to understand the rules that govern molecular recognition. The cocaine-binding site can be characterized topologically as a narrow groove on the protein surface. The antibody utilizes water-mediated hydrogen bonding, and cation-pi and stacking (pi-pi) interactions to provide specificity. Comparison with the previously published structure of the anti-cocaine antibody GNC92H2 shows that binding of a small ligand can be achieved in diverse ways, both in terms of a binding site structure/topology and protein-ligand interactions.
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(as it appears on PubMed at http://www.pubmed.gov), where 15885702 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15885702}}
==About this Structure==
==About this Structure==
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[[Category: Anti-cocaine antibody]]
[[Category: Anti-cocaine antibody]]
[[Category: Fab]]
[[Category: Fab]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:51:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:24:18 2008''

Revision as of 13:24, 27 July 2008

Image:1qyg.png

Template:STRUCTURE 1qyg

ANTI-COCAINE ANTIBODY M82G2 COMPLEXED WITH BENZOYLECGONINE

Template:ABSTRACT PUBMED 15885702

About this Structure

Full crystallographic information is available from OCA.

Reference

Diversity in hapten recognition: structural study of an anti-cocaine antibody M82G2., Pozharski E, Moulin A, Hewagama A, Shanafelt AB, Petsko GA, Ringe D, J Mol Biol. 2005 Jun 10;349(3):570-82. Epub 2005 Apr 21. PMID:15885702

Page seeded by OCA on Sun Jul 27 16:24:18 2008

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