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1zyr

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[[Image:1zyr.gif|left|200px]]
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{{STRUCTURE_1zyr| PDB=1zyr | SCENE= }}
{{STRUCTURE_1zyr| PDB=1zyr | SCENE= }}
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'''Structure of Thermus thermophilus RNA polymerase holoenzyme in complex with the antibiotic streptolydigin'''
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===Structure of Thermus thermophilus RNA polymerase holoenzyme in complex with the antibiotic streptolydigin===
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==Overview==
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We define the target, mechanism, and structural basis of inhibition of bacterial RNA polymerase (RNAP) by the tetramic acid antibiotic streptolydigin (Stl). Stl binds to a site adjacent to but not overlapping the RNAP active center and stabilizes an RNAP-active-center conformational state with a straight-bridge helix. The results provide direct support for the proposals that alternative straight-bridge-helix and bent-bridge-helix RNAP-active-center conformations exist and that cycling between straight-bridge-helix and bent-bridge-helix RNAP-active-center conformations is required for RNAP function. The results set bounds on models for RNAP function and suggest strategies for design of novel antibacterial agents.
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(as it appears on PubMed at http://www.pubmed.gov), where 16122422 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16122422}}
==About this Structure==
==About this Structure==
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[[Category: Streptolydigin]]
[[Category: Streptolydigin]]
[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:14:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:33:21 2008''

Revision as of 13:33, 27 July 2008

Image:1zyr.png

Template:STRUCTURE 1zyr

Structure of Thermus thermophilus RNA polymerase holoenzyme in complex with the antibiotic streptolydigin

Template:ABSTRACT PUBMED 16122422

About this Structure

1ZYR is a Protein complex structure of sequences from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation., Tuske S, Sarafianos SG, Wang X, Hudson B, Sineva E, Mukhopadhyay J, Birktoft JJ, Leroy O, Ismail S, Clark AD Jr, Dharia C, Napoli A, Laptenko O, Lee J, Borukhov S, Ebright RH, Arnold E, Cell. 2005 Aug 26;122(4):541-52. PMID:16122422

Page seeded by OCA on Sun Jul 27 16:33:21 2008

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