2dtg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2dtg.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2dtg.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2dtg| PDB=2dtg | SCENE= }}
{{STRUCTURE_2dtg| PDB=2dtg | SCENE= }}
-
'''Insulin receptor (IR) ectodomain in complex with fab's'''
+
===Insulin receptor (IR) ectodomain in complex with fab's===
-
==Overview==
+
<!--
-
The insulin receptor is a phylogenetically ancient tyrosine kinase receptor found in organisms as primitive as cnidarians and insects. In higher organisms it is essential for glucose homeostasis, whereas the closely related insulin-like growth factor receptor (IGF-1R) is involved in normal growth and development. The insulin receptor is expressed in two isoforms, IR-A and IR-B; the former also functions as a high-affinity receptor for IGF-II and is implicated, along with IGF-1R, in malignant transformation. Here we present the crystal structure at 3.8 A resolution of the IR-A ectodomain dimer, complexed with four Fabs from the monoclonal antibodies 83-7 and 83-14 (ref. 4), grown in the presence of a fragment of an insulin mimetic peptide. The structure reveals the domain arrangement in the disulphide-linked ectodomain dimer, showing that the insulin receptor adopts a folded-over conformation that places the ligand-binding regions in juxtaposition. This arrangement is very different from previous models. It shows that the two L1 domains are on opposite sides of the dimer, too far apart to allow insulin to bind both L1 domains simultaneously as previously proposed. Instead, the structure implicates the carboxy-terminal surface of the first fibronectin type III domain as the second binding site involved in high-affinity binding.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16957736}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16957736 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16957736}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Ir ectodomain]]
[[Category: Ir ectodomain]]
[[Category: X-ray crystallography]]
[[Category: X-ray crystallography]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 01:20:15 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:36:16 2008''

Revision as of 13:36, 27 July 2008

Image:2dtg.png

Template:STRUCTURE 2dtg

Insulin receptor (IR) ectodomain in complex with fab's

Template:ABSTRACT PUBMED 16957736

About this Structure

2DTG is a Single protein structure of sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of the insulin receptor ectodomain reveals a folded-over conformation., McKern NM, Lawrence MC, Streltsov VA, Lou MZ, Adams TE, Lovrecz GO, Elleman TC, Richards KM, Bentley JD, Pilling PA, Hoyne PA, Cartledge KA, Pham TM, Lewis JL, Sankovich SE, Stoichevska V, Da Silva E, Robinson CP, Frenkel MJ, Sparrow LG, Fernley RT, Epa VC, Ward CW, Nature. 2006 Sep 14;443(7108):218-21. Epub 2006 Sep 6. PMID:16957736

Page seeded by OCA on Sun Jul 27 16:36:16 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2dtg"
Personal tools