1nkp

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[[Image:1nkp.gif|left|200px]]
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{{STRUCTURE_1nkp| PDB=1nkp | SCENE= }}
{{STRUCTURE_1nkp| PDB=1nkp | SCENE= }}
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'''Crystal structure of Myc-Max recognizing DNA'''
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===Crystal structure of Myc-Max recognizing DNA===
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==Overview==
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X-ray structures of the basic/helix-loop-helix/leucine zipper (bHLHZ) domains of Myc-Max and Mad-Max heterodimers bound to their common DNA target (Enhancer or E box hexanucleotide, 5'-CACGTG-3') have been determined at 1.9 A and 2.0 A resolution, respectively. E box recognition by these two structurally similar transcription factor pairs determines whether a cell will divide and proliferate (Myc-Max) or differentiate and become quiescent (Mad-Max). Deregulation of Myc has been implicated in the development of many human cancers, including Burkitt's lymphoma, neuroblastomas, and small cell lung cancers. Both quasisymmetric heterodimers resemble the symmetric Max homodimer, albeit with marked structural differences in the coiled-coil leucine zipper regions that explain preferential homo- and heteromeric dimerization of these three evolutionarily related DNA-binding proteins. The Myc-Max heterodimer, but not its Mad-Max counterpart, dimerizes to form a bivalent heterotetramer, which explains how Myc can upregulate expression of genes with promoters bearing widely separated E boxes.
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(as it appears on PubMed at http://www.pubmed.gov), where 12553908 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12553908}}
==About this Structure==
==About this Structure==
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[[Category: Oncogene]]
[[Category: Oncogene]]
[[Category: Transcription]]
[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:38:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:38:27 2008''

Revision as of 13:38, 27 July 2008

Image:1nkp.png

Template:STRUCTURE 1nkp

Crystal structure of Myc-Max recognizing DNA

Template:ABSTRACT PUBMED 12553908

About this Structure

1NKP is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

X-ray structures of Myc-Max and Mad-Max recognizing DNA. Molecular bases of regulation by proto-oncogenic transcription factors., Nair SK, Burley SK, Cell. 2003 Jan 24;112(2):193-205. PMID:12553908

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