1x9z

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{{Seed}}
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[[Image:1x9z.png|left|200px]]
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{{STRUCTURE_1x9z| PDB=1x9z | SCENE= }}
{{STRUCTURE_1x9z| PDB=1x9z | SCENE= }}
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'''Crystal structure of the MutL C-terminal domain'''
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===Crystal structure of the MutL C-terminal domain===
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==Overview==
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MutL assists the mismatch recognition protein MutS to initiate and coordinate mismatch repair in species ranging from bacteria to humans. The MutL N-terminal ATPase domain is highly conserved, but the C-terminal region shares little sequence similarity among MutL homologs. We report here the crystal structure of the Escherichia coli MutL C-terminal dimerization domain and the likelihood of its conservation among MutL homologs. A 100-residue proline-rich linker between the ATPase and dimerization domains, which generates a large central cavity in MutL dimers, tolerates sequence substitutions and deletions of one-third of its length with no functional consequences in vivo or in vitro. Along the surface of the central cavity, residues essential for DNA binding are located in both the N- and C-terminal domains. Each domain of MutL interacts with UvrD helicase and is required for activating the helicase activity. The DNA-binding capacity of MutL is correlated with the level of UvrD activation. A model of how MutL utilizes its ATPase and DNA-binding activities to mediate mismatch-dependent activation of MutH endonuclease and UvrD helicase is proposed.
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The line below this paragraph, {{ABSTRACT_PUBMED_15470502}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15470502 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15470502}}
==About this Structure==
==About this Structure==
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[[Category: Alpha-beta fold]]
[[Category: Alpha-beta fold]]
[[Category: Dimer]]
[[Category: Dimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:45:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:39:58 2008''

Revision as of 13:40, 27 July 2008

Image:1x9z.png

Template:STRUCTURE 1x9z

Crystal structure of the MutL C-terminal domain

Template:ABSTRACT PUBMED 15470502

About this Structure

1X9Z is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of the MutL C-terminal domain: a model of intact MutL and its roles in mismatch repair., Guarne A, Ramon-Maiques S, Wolff EM, Ghirlando R, Hu X, Miller JH, Yang W, EMBO J. 2004 Oct 27;23(21):4134-45. Epub 2004 Oct 7. PMID:15470502

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