1s1q

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{{Seed}}
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{{STRUCTURE_1s1q| PDB=1s1q | SCENE= }}
{{STRUCTURE_1s1q| PDB=1s1q | SCENE= }}
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'''TSG101(UEV) domain in complex with Ubiquitin'''
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===TSG101(UEV) domain in complex with Ubiquitin===
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==Overview==
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The UEV domain of the TSG101 protein functions in both HIV-1 budding and the vacuolar protein sorting (VPS) pathway, where it binds ubiquitylated proteins as they are sorted into vesicles that bud into late endosomal compartments called multivesicular bodies (MVBs). TSG101 UEV-ubiquitin interactions are therefore important for delivery of both substrates and hydrolytic enzymes to lysosomes, which receive proteins via fusion with MVBs. Here, we report the crystal structure of the TSG101 UEV domain in complex with ubiquitin at 2.0 A resolution. TSG101 UEV contacts the Ile44 surface and an adjacent loop of ubiquitin through a highly solvated interface. Mutations that disrupt the interface inhibit MVB sorting, and the structure also explains how the TSG101 UEV can independently bind its ubiquitin and Pro-Thr/Ser-Ala-Pro peptide ligands. Remarkably, comparison with mapping data from other UEV and related E2 proteins indicates that although the different E2/UEV domains share the same structure and have conserved ubiquitin binding activity, they bind through very different interfaces.
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The line below this paragraph, {{ABSTRACT_PUBMED_15053872}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15053872 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15053872}}
==About this Structure==
==About this Structure==
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[[Category: Sundquist, W I.]]
[[Category: Sundquist, W I.]]
[[Category: Heterodimer]]
[[Category: Heterodimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:11:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:45:45 2008''

Revision as of 13:45, 27 July 2008

Image:1s1q.png

Template:STRUCTURE 1s1q

TSG101(UEV) domain in complex with Ubiquitin

Template:ABSTRACT PUBMED 15053872

About this Structure

1S1Q is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Ubiquitin recognition by the human TSG101 protein., Sundquist WI, Schubert HL, Kelly BN, Hill GC, Holton JM, Hill CP, Mol Cell. 2004 Mar 26;13(6):783-9. PMID:15053872

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