2qf7

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[[Image:2qf7.jpg|left|200px]]
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{{STRUCTURE_2qf7| PDB=2qf7 | SCENE= }}
{{STRUCTURE_2qf7| PDB=2qf7 | SCENE= }}
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'''Crystal structure of a complete multifunctional pyruvate carboxylase from Rhizobium etli'''
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===Crystal structure of a complete multifunctional pyruvate carboxylase from Rhizobium etli===
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==Overview==
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Biotin-dependent multifunctional enzymes carry out metabolically important carboxyl group transfer reactions and are potential targets for the treatment of obesity and type 2 diabetes. These enzymes use a tethered biotin cofactor to carry an activated carboxyl group between distantly spaced active sites. The mechanism of this transfer has remained poorly understood. Here we report the complete structure of pyruvate carboxylase at 2.0 angstroms resolution, which shows its domain arrangement. The structure, when combined with mutagenic analysis, shows that intermediate transfer occurs between active sites on separate polypeptide chains. In addition, domain rearrangements associated with activator binding decrease the distance between active-site pairs, providing a mechanism for allosteric activation. This description provides insight into the function of biotin-dependent enzymes and presents a new paradigm for multifunctional enzyme catalysis.
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(as it appears on PubMed at http://www.pubmed.gov), where 17717183 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17717183}}
==About this Structure==
==About this Structure==
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[[Category: Multi-domain]]
[[Category: Multi-domain]]
[[Category: Multi-functional]]
[[Category: Multi-functional]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:51:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:47:25 2008''

Revision as of 13:47, 27 July 2008

Image:2qf7.png

Template:STRUCTURE 2qf7

Crystal structure of a complete multifunctional pyruvate carboxylase from Rhizobium etli

Template:ABSTRACT PUBMED 17717183

About this Structure

2QF7 is a Single protein structure of sequence from Rhizobium etli. Full crystallographic information is available from OCA.

Reference

Domain architecture of pyruvate carboxylase, a biotin-dependent multifunctional enzyme., St Maurice M, Reinhardt L, Surinya KH, Attwood PV, Wallace JC, Cleland WW, Rayment I, Science. 2007 Aug 24;317(5841):1076-9. PMID:17717183

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