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1u34

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[[Image:1u34.gif|left|200px]]
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{{STRUCTURE_1u34| PDB=1u34 | SCENE= }}
{{STRUCTURE_1u34| PDB=1u34 | SCENE= }}
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'''3D NMR structure of the first extracellular domain of CRFR-2beta, a type B1 G-protein coupled receptor'''
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===3D NMR structure of the first extracellular domain of CRFR-2beta, a type B1 G-protein coupled receptor===
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==Overview==
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The corticotropin-releasing factor (CRF) ligand family has diverse effects on the CNS, including the modulation of the stress response. The ligands' effects are mediated by binding to CRF G protein-coupled receptors. We have determined the 3D NMR structure of the N-terminal extracellular domain (ECD1) of the mouse CRF receptor 2beta, which is the major ligand recognition domain, and identified its ligand binding site by chemical-shift perturbation experiments. The fold is identified as a short consensus repeat (SCR), a common protein interaction module. Mutagenesis reveals the integrity of the hormone-binding site in the full-length receptor. This study proposes that the ECD1 captures the C-terminal segment of the ligand, whose N terminus then penetrates into the transmembrane region of the receptor to initiate signaling. Key residues of SCR in the ECD1 are conserved in the G protein-coupled receptor subfamily, suggesting the SCR fold in all of the ECD1s of this subfamily.
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(as it appears on PubMed at http://www.pubmed.gov), where 15326300 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15326300}}
==About this Structure==
==About this Structure==
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1U34 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U34 OCA].
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1U34 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U34 OCA].
==Reference==
==Reference==
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[[Category: Vale, W W.]]
[[Category: Vale, W W.]]
[[Category: Beta sheets and loop]]
[[Category: Beta sheets and loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:42:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:53:29 2008''

Revision as of 13:53, 27 July 2008

Image:1u34.png

Template:STRUCTURE 1u34

3D NMR structure of the first extracellular domain of CRFR-2beta, a type B1 G-protein coupled receptor

Template:ABSTRACT PUBMED 15326300

About this Structure

1U34 is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor., Grace CR, Perrin MH, DiGruccio MR, Miller CL, Rivier JE, Vale WW, Riek R, Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12836-41. Epub 2004 Aug 23. PMID:15326300

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