2qvb

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{{STRUCTURE_2qvb| PDB=2qvb | SCENE= }}
{{STRUCTURE_2qvb| PDB=2qvb | SCENE= }}
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'''Crystal Structure of Haloalkane Dehalogenase Rv2579 from Mycobacterium tuberculosis'''
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===Crystal Structure of Haloalkane Dehalogenase Rv2579 from Mycobacterium tuberculosis===
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==Overview==
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Haloalkane dehalogenases are enzymes well known to be important in bioremediation; the organisms from which they are produced are able to clean up toxic organohalides from polluted environments. However, besides being found in such contaminated environments, these enzymes have also been found in root or tissue-colonizing bacterial species. The haloalkane dehalogenase Rv2579 from Mycobacterium tuberculosis H37Rv has been cloned, expressed, purified and its crystal structure determined at high resolution (1.2A). In addition, the crystal structure of the enzyme has been determined in complex with the product from the reaction with 1,3-dibromopropane, i.e. 1,3-propanediol and in complex with the classical substrate of haloalkane dehalogenases, 1,2-dichloroethane. The enzyme is a two-domain protein having a catalytic domain of an alpha/beta hydrolase fold and a cap domain. The active site residues and the halide-stabilizing residues have been identified as Asp109, Glu133, His273, Asn39 and Trp110. Its overall structure is similar to those of other known haloalkane dehalogenases. Its mechanism of action involves an S(N)2 nucleophilic displacement.
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(as it appears on PubMed at http://www.pubmed.gov), where 18062934 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18062934}}
==About this Structure==
==About this Structure==
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[[Category: Tbsgc]]
[[Category: Tbsgc]]
[[Category: X-ray crystallography]]
[[Category: X-ray crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:45:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:53:33 2008''

Revision as of 13:53, 27 July 2008

Image:2qvb.png

Template:STRUCTURE 2qvb

Crystal Structure of Haloalkane Dehalogenase Rv2579 from Mycobacterium tuberculosis

Template:ABSTRACT PUBMED 18062934

About this Structure

2QVB is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

X-ray crystal structure of Mycobacterium tuberculosis haloalkane dehalogenase Rv2579., Mazumdar PA, Hulecki JC, Cherney MM, Garen CR, James MN, Biochim Biophys Acta. 2008 Feb;1784(2):351-62. Epub 2007 Nov 13. PMID:18062934

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