1t55

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1t55.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1t55.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1t55| PDB=1t55 | SCENE= }}
{{STRUCTURE_1t55| PDB=1t55 | SCENE= }}
-
'''Antibiotic Activity and Structural Analysis of a Scorpion-derived Antimicrobial peptide IsCT and Its Analogs'''
+
===Antibiotic Activity and Structural Analysis of a Scorpion-derived Antimicrobial peptide IsCT and Its Analogs===
-
==Overview==
+
<!--
-
IsCT is a non-cell-selective antimicrobial peptide isolated from the scorpion Opisthacanthus madagascariensis that has potent cytolytic activity against both mammalian and bacterial cells. To investigate the structure-activity relationships of IsCT and to design novel peptide antibiotics with bacterial cell selectivity, we synthesized several analogs of IsCT and determined their three-dimensional structures in solution by 2D-NMR spectroscopy. IsCT has a linear alpha-helical structure from Gly3 to Phe13, and [K7]-IsCT has a linear alpha-helical structure from Leu2 to Phe13. [K7, P8, K11]-IsCT, which has a bend in its middle region, exhibited the highest antibacterial activity without hemolytic activity, suggesting that its proline-induced bend is an important determinant of this selectivity. Tryptophan fluorescence showed that the high selectivity of [K7, P8, K11]-IsCT toward bacterial cells is closely correlated with its highly selective interaction with negatively charged phospholipids. Its potent activity against antibiotic-resistant bacteria suggests that [K7, P8, K11]-IsCT may serve as a promising lead candidate in the development of new peptide antibiotics.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15369808}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15369808 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15369808}}
==About this Structure==
==About this Structure==
-
1T55 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Opisthacanthus_madagascariensis Opisthacanthus madagascariensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T55 OCA].
+
1T55 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Opisthacanthus_madagascariensis Opisthacanthus madagascariensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T55 OCA].
==Reference==
==Reference==
Line 29: Line 33:
[[Category: Shin, S Y.]]
[[Category: Shin, S Y.]]
[[Category: Coil-helix]]
[[Category: Coil-helix]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:32:19 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:54:09 2008''

Revision as of 13:54, 27 July 2008

Image:1t55.png

Template:STRUCTURE 1t55

Antibiotic Activity and Structural Analysis of a Scorpion-derived Antimicrobial peptide IsCT and Its Analogs

Template:ABSTRACT PUBMED 15369808

About this Structure

1T55 is a Single protein structure of sequence from Opisthacanthus madagascariensis. Full experimental information is available from OCA.

Reference

Antibiotic activity and structural analysis of the scorpion-derived antimicrobial peptide IsCT and its analogs., Lee K, Shin SY, Kim K, Lim SS, Hahm KS, Kim Y, Biochem Biophys Res Commun. 2004 Oct 15;323(2):712-9. PMID:15369808

Page seeded by OCA on Sun Jul 27 16:54:09 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1t55"
Personal tools