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1xh3

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{{STRUCTURE_1xh3| PDB=1xh3 | SCENE= }}
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'''Conformational Restraints and Flexibility of 14-Meric Peptides in Complex with HLA-B*3501'''
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===Conformational Restraints and Flexibility of 14-Meric Peptides in Complex with HLA-B*3501===
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==Overview==
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Human HLA-B*3501 binds an antigenic peptide of 14-aa length derived from an alternative reading frame of M-CSF with high affinity. Due to its extraordinary length, the exact HLA binding mode was unpredictable. The crystal structure of HLA-B*3501 at 1.5 A shows that the N and C termini of the peptide are embedded in the A and F pockets, respectively, similar to a peptide of normal length. The central part of the 14-meric peptide bulges flexibly out of the groove. Two variants of the alternative reading frame of M-CSF peptide substituted at P2 or P2 and P9 with Ala display weak or no T cell activation. Their structure differs mainly in flexibility and conformation from the agonistic peptide. Moreover, the variants induce subtle changes of MHC alpha-helical regions implicated as critical for TCR contact. The TCR specifically recognizing this peptide/MHC complex exhibits CDR3 length within the normal range, suggesting major conformational adaptations of this receptor upon peptide/MHC binding. Thus, the potential antigenic repertoire recognizable by CTLs is larger than currently thought.
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{{ABSTRACT_PUBMED_15494511}}
==Disease==
==Disease==
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[[Category: Weiss, S.]]
[[Category: Weiss, S.]]
[[Category: Immune system]]
[[Category: Immune system]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:01:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:01:15 2008''

Revision as of 14:01, 27 July 2008

Image:1xh3.png

Template:STRUCTURE 1xh3

Contents

Conformational Restraints and Flexibility of 14-Meric Peptides in Complex with HLA-B*3501

Template:ABSTRACT PUBMED 15494511

Disease

Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]

About this Structure

1XH3 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Conformational restraints and flexibility of 14-meric peptides in complex with HLA-B*3501., Probst-Kepper M, Hecht HJ, Herrmann H, Janke V, Ocklenburg F, Klempnauer J, van den Eynde BJ, Weiss S, J Immunol. 2004 Nov 1;173(9):5610-6. PMID:15494511

Page seeded by OCA on Sun Jul 27 17:01:15 2008

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