2an6

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{{STRUCTURE_2an6| PDB=2an6 | SCENE= }}
{{STRUCTURE_2an6| PDB=2an6 | SCENE= }}
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'''Protein-peptide complex'''
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===Protein-peptide complex===
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==Overview==
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The Siah family of RING proteins function as ubiquitin ligase components, contributing to the degradation of multiple targets involved in cell growth, differentiation, angiogenesis, oncogenesis, and inflammation. Previously, a binding motif (degron) was recognized in many of the Siah degradation targets, suggesting that Siah itself may facilitate substrate recognition. We report the crystal structure of the Siah in complex with a peptide containing the degron motif. Binding is within a groove formed in part by the zinc fingers and the first two beta strands of the TRAF-C domain of Siah. We show that residues in the degron, previously described to facilitate binding to Siah, interact with the protein. Mutagenesis of Siah at sites of interaction also abrogates both in vitro peptide binding and destabilization of a known Siah target.
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(as it appears on PubMed at http://www.pubmed.gov), where 16615911 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16615911}}
==About this Structure==
==About this Structure==
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[[Category: Polekhina, G.]]
[[Category: Polekhina, G.]]
[[Category: Protein-peptide complex]]
[[Category: Protein-peptide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:14:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:01:41 2008''

Revision as of 14:01, 27 July 2008

Image:2an6.png

Template:STRUCTURE 2an6

Protein-peptide complex

Template:ABSTRACT PUBMED 16615911

About this Structure

2AN6 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Elucidation of the substrate binding site of Siah ubiquitin ligase., House CM, Hancock NC, Moller A, Cromer BA, Fedorov V, Bowtell DD, Parker MW, Polekhina G, Structure. 2006 Apr;14(4):695-701. PMID:16615911

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