2uw0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2uw0.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2uw0.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2uw0| PDB=2uw0 | SCENE= }}
{{STRUCTURE_2uw0| PDB=2uw0 | SCENE= }}
-
'''STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 6-(4-(4-(4-CHLORO-PHENYL)-PIPERIDIN-4-YL)-PHENYL)-9H-PURINE'''
+
===STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 6-(4-(4-(4-CHLORO-PHENYL)-PIPERIDIN-4-YL)-PHENYL)-9H-PURINE===
-
==Overview==
+
<!--
-
6-phenylpurines were identified as novel, ATP-competitive inhibitors of protein kinase B (PKB/Akt) from a fragment-based screen and were rapidly progressed to potent compounds using iterative protein-ligand crystallography with a PKA-PKB chimeric protein. An elaborated lead compound showed cell growth inhibition and effects on cellular signaling pathways characteristic of PKB inhibition.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17451235}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17451235 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17451235}}
==About this Structure==
==About this Structure==
Line 43: Line 47:
[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Transferase/inhibitor complex]]
[[Category: Transferase/inhibitor complex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:37:18 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:03:37 2008''

Revision as of 14:03, 27 July 2008

Image:2uw0.png

Template:STRUCTURE 2uw0

STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 6-(4-(4-(4-CHLORO-PHENYL)-PIPERIDIN-4-YL)-PHENYL)-9H-PURINE

Template:ABSTRACT PUBMED 17451235

About this Structure

2UW0 is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design., Donald A, McHardy T, Rowlands MG, Hunter LJ, Davies TG, Berdini V, Boyle RG, Aherne GW, Garrett MD, Collins I, J Med Chem. 2007 May 17;50(10):2289-92. Epub 2007 Apr 24. PMID:17451235

Page seeded by OCA on Sun Jul 27 17:03:37 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2uw0"
Personal tools