1oxc

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[[Image:1oxc.jpg|left|200px]]
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{{Seed}}
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[[Image:1oxc.png|left|200px]]
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{{STRUCTURE_1oxc| PDB=1oxc | SCENE= }}
{{STRUCTURE_1oxc| PDB=1oxc | SCENE= }}
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'''LecB (PA-LII) in complex with FUCOSE'''
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===LecB (PA-LII) in complex with FUCOSE===
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==Overview==
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The crystal structure of Pseudomonas aeruginosa fucose-specific lectin LecB was determined in its metal-bound and metal-free state as well as in complex with fucose, mannose and fructopyranose. All three monosaccharides bind isosterically via direct interactions with two calcium ions as well as direct hydrogen bonds with several side-chains. The higher affinity for fucose is explained by the details of the binding site around C6 and O1 of fucose. In the mannose and fructose complexes, a carboxylate oxygen atom and one or two hydroxyl groups are partly shielded from solvent upon sugar binding, preventing them from completely fulfilling their hydrogen bonding potential. In the fucose complex, no such defects are observed. Instead, C6 makes favourable interactions with a small hydrophobic patch. Upon demetallization, the C terminus as well as the otherwise rigid metal-binding loop become more mobile and adopt multiple conformations.
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(as it appears on PubMed at http://www.pubmed.gov), where 12909014 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12909014}}
==About this Structure==
==About this Structure==
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[[Category: Carbohydrate]]
[[Category: Carbohydrate]]
[[Category: Lectin]]
[[Category: Lectin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:23:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:03:37 2008''

Revision as of 14:03, 27 July 2008

Image:1oxc.png

Template:STRUCTURE 1oxc

LecB (PA-LII) in complex with FUCOSE

Template:ABSTRACT PUBMED 12909014

About this Structure

1OXC is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Structural basis of carbohydrate recognition by the lectin LecB from Pseudomonas aeruginosa., Loris R, Tielker D, Jaeger KE, Wyns L, J Mol Biol. 2003 Aug 22;331(4):861-70. PMID:12909014

Page seeded by OCA on Sun Jul 27 17:03:37 2008

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