This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2i9t

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2i9t.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2i9t.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2i9t| PDB=2i9t | SCENE= }}
{{STRUCTURE_2i9t| PDB=2i9t | SCENE= }}
-
'''Structure of NF-kB p65-p50 heterodimer bound to PRDII element of B-interferon promoter'''
+
===Structure of NF-kB p65-p50 heterodimer bound to PRDII element of B-interferon promoter===
-
==Overview==
+
<!--
-
Upon viral infection, NF-kappaB translocates to the nucleus and activates the IFN-beta gene by binding to the PRDII element. Strikingly, NF-kappaB loses its ability to activate the IFN-beta gene when the PRDII element is substituted by closely related sites. We report here the crystal structure of NF-kappaB p50/p65 heterodimer bound to the PRDII element from the IFN-beta promoter. The structure reveals an unexpected alteration in configuration, in which the p50 specificity domain moves by as much as approximately 9 A when compared to NF-kappaB heterodimer bound to the immunoglobulin kappaB site (Ig-kappaB) while maintaining the same base-specific contacts with the DNA. Taken together, the structure offers new insights into the allosteric effects of closely related DNA sites on the configuration of NF-kappaB and its transcriptional selectivity.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12005436}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12005436 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12005436}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Thanos, D.]]
[[Category: Thanos, D.]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:14:02 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:04:20 2008''

Revision as of 14:04, 27 July 2008

Image:2i9t.png

Template:STRUCTURE 2i9t

Structure of NF-kB p65-p50 heterodimer bound to PRDII element of B-interferon promoter

Template:ABSTRACT PUBMED 12005436

About this Structure

2I9T is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of NF-kappaB p50/p65 heterodimer bound to the PRDII DNA element from the interferon-beta promoter., Escalante CR, Shen L, Thanos D, Aggarwal AK, Structure. 2002 Mar;10(3):383-91. PMID:12005436

Page seeded by OCA on Sun Jul 27 17:04:20 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2i9t"
Personal tools