2i9t

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[[Image:2i9t.gif|left|200px]]
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{{Seed}}
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[[Image:2i9t.png|left|200px]]
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{{STRUCTURE_2i9t| PDB=2i9t | SCENE= }}
{{STRUCTURE_2i9t| PDB=2i9t | SCENE= }}
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'''Structure of NF-kB p65-p50 heterodimer bound to PRDII element of B-interferon promoter'''
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===Structure of NF-kB p65-p50 heterodimer bound to PRDII element of B-interferon promoter===
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==Overview==
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Upon viral infection, NF-kappaB translocates to the nucleus and activates the IFN-beta gene by binding to the PRDII element. Strikingly, NF-kappaB loses its ability to activate the IFN-beta gene when the PRDII element is substituted by closely related sites. We report here the crystal structure of NF-kappaB p50/p65 heterodimer bound to the PRDII element from the IFN-beta promoter. The structure reveals an unexpected alteration in configuration, in which the p50 specificity domain moves by as much as approximately 9 A when compared to NF-kappaB heterodimer bound to the immunoglobulin kappaB site (Ig-kappaB) while maintaining the same base-specific contacts with the DNA. Taken together, the structure offers new insights into the allosteric effects of closely related DNA sites on the configuration of NF-kappaB and its transcriptional selectivity.
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The line below this paragraph, {{ABSTRACT_PUBMED_12005436}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12005436 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12005436}}
==About this Structure==
==About this Structure==
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[[Category: Thanos, D.]]
[[Category: Thanos, D.]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:14:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:04:20 2008''

Revision as of 14:04, 27 July 2008

Image:2i9t.png

Template:STRUCTURE 2i9t

Structure of NF-kB p65-p50 heterodimer bound to PRDII element of B-interferon promoter

Template:ABSTRACT PUBMED 12005436

About this Structure

2I9T is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of NF-kappaB p50/p65 heterodimer bound to the PRDII DNA element from the interferon-beta promoter., Escalante CR, Shen L, Thanos D, Aggarwal AK, Structure. 2002 Mar;10(3):383-91. PMID:12005436

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