1onq

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{{STRUCTURE_1onq| PDB=1onq | SCENE= }}
{{STRUCTURE_1onq| PDB=1onq | SCENE= }}
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'''Crystal Structure of CD1a in Complex with a Sulfatide'''
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===Crystal Structure of CD1a in Complex with a Sulfatide===
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==Overview==
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CD1 antigens bind a variety of self and foreign lipid and glycolipid antigens for presentation to CD1-restricted T cell receptors (TCRs). Here we report the crystal structure of human CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A. The lipid adopts an S-shaped conformation, with the sphingosine chain completely buried in the A' pocket and the fatty acid chain emerging from the interface of the A' pocket into the more exposed F' pocket. The headgroup is anchored in the A'-F' junction and protrudes into the F' pocket for TCR recognition. Because the A' pocket is narrow with a fixed terminus, it can act as a molecular 'ruler' to select alkyl chains of a particular length.
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(as it appears on PubMed at http://www.pubmed.gov), where 12833155 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12833155}}
==Disease==
==Disease==
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[[Category: Beta sheet platform]]
[[Category: Beta sheet platform]]
[[Category: Protein-glycolipid complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:04:34 2008''

Revision as of 14:04, 27 July 2008

Image:1onq.png

Template:STRUCTURE 1onq

Contents

Crystal Structure of CD1a in Complex with a Sulfatide

Template:ABSTRACT PUBMED 12833155

Disease

Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]

About this Structure

1ONQ is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A., Zajonc DM, Elsliger MA, Teyton L, Wilson IA, Nat Immunol. 2003 Aug;4(8):808-15. Epub 2003 Jun 29. PMID:12833155

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