1vhr

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{{STRUCTURE_1vhr| PDB=1vhr | SCENE= }}
{{STRUCTURE_1vhr| PDB=1vhr | SCENE= }}
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'''HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE'''
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===HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE===
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==Overview==
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Dual specificity protein phosphatases (DSPs) regulate mitogenic signal transduction and control the cell cycle. Here, the crystal structure of a human DSP, vaccinia H1-related phosphatase (or VHR), was determined at 2.1 angstrom resolution. A shallow active site pocket in VHR allows for the hydrolysis of phosphorylated serine, threonine, or tyrosine protein residues, whereas the deeper active site of protein tyrosine phosphatases (PTPs) restricts substrate specificity to only phosphotyrosine. Positively charged crevices near the active site may explain the enzyme's preference for substrates with two phosphorylated residues. The VHR structure defines a conserved structural scaffold for both DSPs and PTPs. A "recognition region," connecting helix alpha1 to strand beta1, may determine differences in substrate specificity between VHR, the PTPs, and other DSPs.
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{{ABSTRACT_PUBMED_8650541}}
==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Protein dual-specificity phosphatase]]
[[Category: Protein dual-specificity phosphatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:33:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:05:25 2008''

Revision as of 14:05, 27 July 2008

Image:1vhr.png

Template:STRUCTURE 1vhr

HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE

Template:ABSTRACT PUBMED 8650541

About this Structure

1VHR is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the dual specificity protein phosphatase VHR., Yuvaniyama J, Denu JM, Dixon JE, Saper MA, Science. 1996 May 31;272(5266):1328-31. PMID:8650541

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