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2mag

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[[Image:2mag.gif|left|200px]]
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{{STRUCTURE_2mag| PDB=2mag | SCENE= }}
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'''NMR STRUCTURE OF MAGAININ 2 IN DPC MICELLES, 10 STRUCTURES'''
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===NMR STRUCTURE OF MAGAININ 2 IN DPC MICELLES, 10 STRUCTURES===
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==Overview==
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Magainin2 is a 23-residue antibiotic peptide that disrupts the ionic gradient across certain cell membranes. Two-dimensional 1H NMR spectroscopy was used to investigate the structure of the peptide in three of the membrane environments most commonly employed in biophysical studies. Sequence-specific resonance assignments were determined for the peptide in perdeuterated dodecylphosphocholine (DPC) and sodium dodecylsulfate micelles and confirmed for the peptide in 2,2,2-trifluoroethanol solution. The secondary structure is shown to be helical in all of the solvent systems. The NMR data were used as a set of restraints for a simulated annealing protocol that generated a family of three-dimensional structures of the peptide in DPC micelles, which superimposed best between residues 4 and 20. For these residues, the mean pairwise rms difference for the backbone atoms is 0.47 +/- 0.10 A from the average structure. The calculated peptide structures appear to be curved, with the bend centered at residues Phe12 and Gly13.
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{{ABSTRACT_PUBMED_9090128}}
==About this Structure==
==About this Structure==
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2MAG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MAG OCA].
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2MAG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MAG OCA].
==Reference==
==Reference==
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[[Category: Membrane]]
[[Category: Membrane]]
[[Category: Micelle]]
[[Category: Micelle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:31:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:08:25 2008''

Revision as of 14:08, 27 July 2008

Image:2mag.png

Template:STRUCTURE 2mag

NMR STRUCTURE OF MAGAININ 2 IN DPC MICELLES, 10 STRUCTURES

Template:ABSTRACT PUBMED 9090128

About this Structure

2MAG is a Single protein structure of sequence from Xenopus laevis. Full experimental information is available from OCA.

Reference

Two-dimensional 1H NMR experiments show that the 23-residue magainin antibiotic peptide is an alpha-helix in dodecylphosphocholine micelles, sodium dodecylsulfate micelles, and trifluoroethanol/water solution., Gesell J, Zasloff M, Opella SJ, J Biomol NMR. 1997 Feb;9(2):127-35. PMID:9090128

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