1nt2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1nt2.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1nt2.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1nt2| PDB=1nt2 | SCENE= }}
{{STRUCTURE_1nt2| PDB=1nt2 | SCENE= }}
-
'''CRYSTAL STRUCTURE OF FIBRILLARIN/NOP5P COMPLEX'''
+
===CRYSTAL STRUCTURE OF FIBRILLARIN/NOP5P COMPLEX===
-
==Overview==
+
<!--
-
Nop56p and Nop58p are two core proteins of the box C/D snoRNPs that interact concurrently with fibrillarin and snoRNAs to function in enzyme assembly and catalysis. Here we report the 2.9 A resolution co-crystal structure of an archaeal homolog of Nop56p/Nop58p, Nop5p, in complex with fibrillarin from Archaeoglobus fulgidus (AF) and the methyl donor S-adenosyl-L-methionine. The N-terminal domain of Nop5p forms a complementary surface to fibrillarin that serves to anchor the catalytic subunit and to stabilize cofactor binding. A coiled coil in Nop5p mediates dimerization of two fibrillarin-Nop5p heterodimers for optimal interactions with bipartite box C/D RNAs. Structural analysis and complementary biochemical data demonstrate that the conserved C-terminal domain of Nop5p harbors RNA-binding sites. A model of box C/D snoRNP assembly is proposed based on the presented structural and biochemical data.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12598892}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12598892 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12598892}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Binding motif]]
[[Category: Binding motif]]
[[Category: Coiled coil]]
[[Category: Coiled coil]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:56:39 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:11:31 2008''

Revision as of 14:11, 27 July 2008

Image:1nt2.png

Template:STRUCTURE 1nt2

CRYSTAL STRUCTURE OF FIBRILLARIN/NOP5P COMPLEX

Template:ABSTRACT PUBMED 12598892

About this Structure

1NT2 is a Protein complex structure of sequences from Archaeoglobus fulgidus. Full crystallographic information is available from OCA.

Reference

Structure and function of archaeal box C/D sRNP core proteins., Aittaleb M, Rashid R, Chen Q, Palmer JR, Daniels CJ, Li H, Nat Struct Biol. 2003 Apr;10(4):256-63. PMID:12598892

Page seeded by OCA on Sun Jul 27 17:11:31 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1nt2"
Personal tools