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1yrk

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[[Image:1yrk.gif|left|200px]]
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{{STRUCTURE_1yrk| PDB=1yrk | SCENE= }}
{{STRUCTURE_1yrk| PDB=1yrk | SCENE= }}
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'''The C2 Domain of PKC<delta> is a new Phospho-Tyrosine Binding Domain'''
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===The C2 Domain of PKC<delta> is a new Phospho-Tyrosine Binding Domain===
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==Overview==
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In this issue of Cell, report that the C2 domain of the serine/threonine protein kinase Cdelta is a phosphotyrosine binding domain and present the crystal structure of this C2 domain bound to a peptide containing phosphotyrosine. Prior to this work, C2 domains were thought to bind only to phospholipids or to unphosphorylated proteins, and the SH2 and PTB domains were the only signaling domains known to recognize phosphotyrosine. This new role for the C2 domain links phosphotyrosine recognition directly to serine/threonine kinase activity and reveals an unexpected mechanism for crosstalk between distinct signaling pathways.
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(as it appears on PubMed at http://www.pubmed.gov), where 15851022 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15851022}}
==About this Structure==
==About this Structure==
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[[Category: Wu, N.]]
[[Category: Wu, N.]]
[[Category: C2 domain]]
[[Category: C2 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:41:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:14:36 2008''

Revision as of 14:14, 27 July 2008

Image:1yrk.png

Template:STRUCTURE 1yrk

The C2 Domain of PKC<delta> is a new Phospho-Tyrosine Binding Domain

Template:ABSTRACT PUBMED 15851022

About this Structure

1YRK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

C2 can do it, too., Sondermann H, Kuriyan J, Cell. 2005 Apr 22;121(2):158-60. PMID:15851022

Page seeded by OCA on Sun Jul 27 17:14:36 2008

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