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2jj2

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{{STRUCTURE_2jj2| PDB=2jj2 | SCENE= }}
{{STRUCTURE_2jj2| PDB=2jj2 | SCENE= }}
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'''THE STRUCTURE OF F1-ATPASE INHIBITED BY QUERCETIN.'''
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===THE STRUCTURE OF F1-ATPASE INHIBITED BY QUERCETIN.===
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==Overview==
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The structures of F(1)-ATPase from bovine heart mitochondria inhibited with the dietary phytopolyphenol, resveratrol, and with the related polyphenols quercetin and piceatannol have been determined at 2.3-, 2.4- and 2.7-A resolution, respectively. The inhibitors bind to a common site in the inside surface of an annulus made from loops in the three alpha- and three beta-subunits beneath the "crown" of beta-strands in their N-terminal domains. This region of F(1)-ATPase forms a bearing to allow the rotation of the tip of the gamma-subunit inside the annulus during catalysis. The binding site is a hydrophobic pocket between the C-terminal tip of the gamma-subunit and the beta(TP) subunit, and the inhibitors are bound via H-bonds mostly to their hydroxyl moieties mediated by bound water molecules and by hydrophobic interactions. There are no equivalent sites between the gamma-subunit and either the beta(DP) or the beta(E) subunit. The inhibitors probably prevent both the synthetic and hydrolytic activities of the enzyme by blocking both senses of rotation of the gamma-subunit. The beneficial effects of dietary resveratrol may derive in part by preventing mitochondrial ATP synthesis in tumor cells, thereby inducing apoptosis.
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(as it appears on PubMed at http://www.pubmed.gov), where 17698806 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17698806}}
==About this Structure==
==About this Structure==
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[[Category: Transit peptide]]
[[Category: Transit peptide]]
[[Category: Transport]]
[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:00:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:18:57 2008''

Revision as of 14:19, 27 July 2008

Image:2jj2.png

Template:STRUCTURE 2jj2

THE STRUCTURE OF F1-ATPASE INHIBITED BY QUERCETIN.

Template:ABSTRACT PUBMED 17698806

About this Structure

2JJ2 is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols., Gledhill JR, Montgomery MG, Leslie AG, Walker JE, Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13632-7. Epub 2007 Aug 13. PMID:17698806

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