1rra

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{{Seed}}
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{{STRUCTURE_1rra| PDB=1rra | SCENE= }}
{{STRUCTURE_1rra| PDB=1rra | SCENE= }}
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'''RIBONUCLEASE A FROM RATTUS NORVEGICUS (COMMON RAT)'''
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===RIBONUCLEASE A FROM RATTUS NORVEGICUS (COMMON RAT)===
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==Overview==
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The three-dimensional structure of rat pancreatic RNase A expressed in Escherichia coli was determined. The backbone conformations of certain critical loops are significantly different in this enzyme compared to its bovine counterpart. However, the core structure of rat RNase A is similar to that of the other members of the pancreatic ribonuclease family. The structural variations within a loop bordering the active site can be correlated with the subtle differences in the enzymatic activities of bovine and rat ribonucleases for different substrates. The most significant difference in the backbone conformation was observed in the loop 15-25. This loop incorporates the subtilisin cleavage site which is responsible for RNase A to RNase S conversion in the bovine enzyme. The rat enzyme does not get cleaved under identical conditions. Molecular docking of this region of the rat enzyme in the active site of subtilisin shows steric incompatibility, although the bovine pancreatic ribonuclease A appropriately fits into this active site. It is therefore inferred that the local conformation of the substrate governs the specificity of subtilisin.
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(as it appears on PubMed at http://www.pubmed.gov), where 10090281 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10090281}}
==About this Structure==
==About this Structure==
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[[Category: Wyns, L.]]
[[Category: Wyns, L.]]
[[Category: Ribonuclease]]
[[Category: Ribonuclease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:49:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:19:08 2008''

Revision as of 14:19, 27 July 2008

Image:1rra.png

Template:STRUCTURE 1rra

RIBONUCLEASE A FROM RATTUS NORVEGICUS (COMMON RAT)

Template:ABSTRACT PUBMED 10090281

About this Structure

1RRA is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

The crystal structure of recombinant rat pancreatic RNase A., Gupta V, Muyldermans S, Wyns L, Salunke DM, Proteins. 1999 Apr 1;35(1):1-12. PMID:10090281

Page seeded by OCA on Sun Jul 27 17:19:08 2008

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