2ht6

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{{STRUCTURE_2ht6| PDB=2ht6 | SCENE= }}
{{STRUCTURE_2ht6| PDB=2ht6 | SCENE= }}
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'''Crystal structure of Human Gem G-domain bound to GDP'''
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===Crystal structure of Human Gem G-domain bound to GDP===
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==Overview==
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Gem, a member of the Rad,Gem/Kir subfamily of small G-proteins, has unique sequence features. We report here the crystallographic structure determination of the Gem G-domain in complex with nucleotide to 2.4 A resolution. Although the basic Ras protein fold is maintained, the Gem switch regions emphatically differ from the Ras paradigm. Our ensuing biochemical characterization indicates that Gem G-domain markedly prefers GDP over GTP. Two known functions of Gem are distinctly affected by spatially separated clusters of mutations.
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{{ABSTRACT_PUBMED_17052716}}
==About this Structure==
==About this Structure==
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[[Category: Opatowsky, Y.]]
[[Category: Opatowsky, Y.]]
[[Category: Small g-protein]]
[[Category: Small g-protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:20:38 2008''

Revision as of 14:20, 27 July 2008

Template:STRUCTURE 2ht6

Crystal structure of Human Gem G-domain bound to GDP

Template:ABSTRACT PUBMED 17052716

About this Structure

2HT6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-function studies of the G-domain from human gem, a novel small G-protein., Opatowsky Y, Sasson Y, Shaked I, Ward Y, Chomsky-Hecht O, Litvak Y, Selinger Z, Kelly K, Hirsch JA, FEBS Lett. 2006 Oct 30;580(25):5959-64. Epub 2006 Oct 6. PMID:17052716

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