2ic2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2ic2.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2ic2.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2ic2| PDB=2ic2 | SCENE= }}
{{STRUCTURE_2ic2| PDB=2ic2 | SCENE= }}
-
'''Crystal Structure of the First FNIII Domain of Ihog'''
+
===Crystal Structure of the First FNIII Domain of Ihog===
-
==Overview==
+
<!--
-
Hedgehog (Hh) signaling molecules mediate key tissue-patterning events during animal development, and inappropriate activation of Hh signaling in adults has been associated with human cancers. Recently, a conserved family of type I integral membrane proteins required for normal response to the Hh signal was discovered. One member of this family, Ihog (interference hedgehog), functions upstream or at the level of Patched (Ptc), but how Ihog participates in Hh signaling remains unclear. Here, we show that heparin binding induces Ihog dimerization and is required to mediate high-affinity interactions between Ihog and Hh. We also present crystal structures of a Hh-binding fragment of Ihog, both alone and complexed with Hh. Heparin is not well ordered in these structures, but a basic cleft in the first FNIII domain of Ihog (IhogFn1) is shown by mutagenesis to mediate heparin binding. These results establish that Hh directly binds Ihog and provide the first demonstration of a specific role for heparin in Hh responsiveness.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17077139}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17077139 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17077139}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Hedgehog]]
[[Category: Hedgehog]]
[[Category: Ihog]]
[[Category: Ihog]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:18:58 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:21:27 2008''

Revision as of 14:21, 27 July 2008

Image:2ic2.png

Template:STRUCTURE 2ic2

Crystal Structure of the First FNIII Domain of Ihog

Template:ABSTRACT PUBMED 17077139

About this Structure

2IC2 is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structure of a heparin-dependent complex of Hedgehog and Ihog., McLellan JS, Yao S, Zheng X, Geisbrecht BV, Ghirlando R, Beachy PA, Leahy DJ, Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17208-13. Epub 2006 Oct 31. PMID:17077139

Page seeded by OCA on Sun Jul 27 17:21:27 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ic2"
Personal tools