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1mvk

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[[Image:1mvk.gif|left|200px]]
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{{STRUCTURE_1mvk| PDB=1mvk | SCENE= }}
{{STRUCTURE_1mvk| PDB=1mvk | SCENE= }}
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'''X-ray structure of the tetrameric mutant of the B1 domain of streptococcal protein G'''
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===X-ray structure of the tetrameric mutant of the B1 domain of streptococcal protein G===
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==Overview==
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The structure of a mutant immunoglobulin-binding B1 domain of streptococcal protein G (GB1), which comprises five conservative changes in hydrophobic core residues, was determined by NMR spectroscopy and X-ray crystallography. The oligomeric state and quaternary structure of the mutant protein are drastically changed from the wild type protein. The mutant structure consists of a symmetric tetramer, with intermolecular strand exchange involving all four units. Four of the five secondary structure elements present in the monomeric wild type GB1 structure are retained in the tetrameric structure, although their intra- and intermolecular interactions are altered. Our results demonstrate that through the acquisition of a moderate number of pivotal point mutations, proteins such as GB1 are able to undergo drastic structural changes, overcoming reduced stability of the monomeric unit by multimerization. The present structure is an illustrative example of how proteins exploit the breadth of conformational space.
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(as it appears on PubMed at http://www.pubmed.gov), where 12379842 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12379842}}
==About this Structure==
==About this Structure==
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[[Category: Channel]]
[[Category: Channel]]
[[Category: Strand-exchanged tetramer]]
[[Category: Strand-exchanged tetramer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:46:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:25:25 2008''

Revision as of 14:25, 27 July 2008

Image:1mvk.png

Template:STRUCTURE 1mvk

X-ray structure of the tetrameric mutant of the B1 domain of streptococcal protein G

Template:ABSTRACT PUBMED 12379842

About this Structure

1MVK is a Single protein structure of sequence from Bacteria. Full crystallographic information is available from OCA.

Reference

Core mutations switch monomeric protein GB1 into an intertwined tetramer., Kirsten Frank M, Dyda F, Dobrodumov A, Gronenborn AM, Nat Struct Biol. 2002 Nov;9(11):877-85. PMID:12379842

Page seeded by OCA on Sun Jul 27 17:25:25 2008

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